Sensory restoration by epidural stimulation of the lateral spinal cord in upper-limb amputees.

ELife
Santosh ChandrasekaranLee E Fisher

Abstract

Restoring somatosensory feedback to people with limb amputations is crucial to improve prosthetic control. Multiple studies have demonstrated that peripheral nerve stimulation and targeted reinnervation can provide somatotopically relevant sensory feedback. While effective, the surgical procedures required for these techniques remain a major barrier to translatability. Here, we demonstrate in four people with upper-limb amputation that epidural spinal cord stimulation (SCS), a common clinical technique to treat pain, evoked somatosensory percepts that were perceived as emanating from the missing arm and hand. Over up to 29 days, stimulation evoked sensory percepts in consistent locations in the missing hand regardless of time since amputation or level of amputation. Evoked sensations were occasionally described as naturalistic (e.g. touch or pressure), but were often paresthesias. Increasing stimulus amplitude increased the perceived intensity linearly, without increasing area of the sensations. These results demonstrate the potential of SCS as a tool to restore somatosensation after amputations.

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Citations

Nov 25, 2020·Nature Biomedical Engineering·Sliman J BensmaiaSilvestro Micera
Nov 19, 2020·Journal of Neurophysiology·Marco Bonizzato
Jun 2, 2021·Nature Biomedical Engineering·Dario FarinaOskar C Aszmann
May 27, 2021·Journal of Neuroengineering and Rehabilitation·Martin A GarenfeldStrahinja Dosen
Oct 14, 2021·Journal of Neurophysiology·Jose L HerreroStephan Bickel

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Methods Mentioned

BETA
amputations
amputation
X-ray

Software Mentioned

Palamedes
MATLAB
SAS

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