Sensory stimulation-dependent plasticity in the cerebellar cortex of alert mice.

PloS One
J Márquez-Ruiz, Guy Cheron

Abstract

In vitro studies have supported the occurrence of cerebellar long-term depression (LTD), an interaction between the parallel fibers and Purkinje cells (PCs) that requires the combined activation of the parallel and climbing fibers. To demonstrate the existence of LTD in alert animals, we investigated the plasticity of local field potentials (LFPs) evoked by electrical stimulation of the whisker pad. The recorded LFP showed two major negative waves corresponding to trigeminal (broken into the N2 and N3 components) and cortical responses. PC unitary extracellular recording showed that N2 and N3 occurred concurrently with PC evoked simple spikes, followed by an evoked complex spike. Polarity inversion of the N3 component at the PC level and N3 amplitude reduction after electrical stimulation of the parallel fiber volley applied on the surface of the cerebellum 2 ms earlier strongly suggest that N3 was related to the parallel fiber-PC synapse activity. LFP measurements elicited by single whisker pad stimulus were performed before and after trains of electrical stimuli given at a frequency of 8 Hz for 10 min. We demonstrated that during this later situation, the stimulation of the PC by parallel and climbing fibers was reinforced. A...Continue Reading

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Citations

Nov 25, 2014·The Cerebellum·Henrik Jörntell
Mar 1, 2016·Frontiers in Cellular Neuroscience·K B RamakrishnanEgidio D'Angelo
Aug 26, 2015·The Cerebellum·Egidio D'AngeloEduardo Ros
Mar 27, 2015·The Cerebellum·G CheronB Dan
Mar 16, 2013·The Anatomical Record : Advances in Integrative Anatomy and Evolutionary Biology·Craig D ByronVirginia Young
Dec 10, 2013·Neural Plasticity·Guy CheronJavier Márquez-Ruiz
Jul 6, 2014·Frontiers in Systems Neuroscience·Laurentiu S PopaTimothy J Ebner
Nov 25, 2014·Nature Communications·Claire PiochonChristian Hansel
Jul 13, 2019·The Journal of Physiology·Heather K TitleyChristian Hansel
Mar 22, 2019·Frontiers in Cellular Neuroscience·Letizia MoscatoEgidio D'Angelo

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