Sentinel Lymph Node Biopsy for Recurrent Melanoma: A Multicenter Study

Annals of Surgical Oncology
Georgia M BeasleyAlicia M Terando

Abstract

Sentinel lymph node biopsy (SLNB) is routinely performed for primary cutaneous melanomas; however, limited data exist for SLNB after locally recurrent (LR) or in-transit (IT) melanoma. Data from three centers performing SLNB for LR/IT melanoma (1997 to the present) were reviewed, with the aim of assessing (1) success rate; (2) SLNB positivity; and (3) prognostic value of SLNB in this population. The study cohort included 107 patients. Management of the primary melanoma included prior SLNB for 56 patients (52%), of whom 10 (18%) were positive and 12 had complete lymph node dissections (CLNDs). In the present study, SLNB was performed for IT disease (48/107, 45%) or LR melanoma (59/107, 55%). A sentinel lymph node (SLN) was removed in 96% (103/107) of cases. Nodes were not removed for four patients due to lymphoscintigraphy failures (2) or nodes not found during surgery (2). SLNB was positive in 41 patients (40%, 95% confidence interval (CI) 31.5-50.5), of whom 35 (88%) had CLND, with 13 (37%) having positive nonsentinel nodes. Median time to disease progression after LR/IT metastasis was 1.4 years (95% CI 0.75-2.0) for patients with a positive SLNB, and 5.9 years (95% CI 1.7-10.2) in SLNB-negative patients (p = 0.18). There was ...Continue Reading

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Citations

Nov 28, 2018·Journal of Surgical Oncology·Minyoung KwakGeorgia M Beasley
Nov 28, 2018·Journal of Surgical Oncology·Edmund K Bartlett
May 11, 2018·Journal of Oncology Practice·Jennifer A PeroneGeorgia M Beasley
Nov 7, 2019·Expert Review of Clinical Pharmacology·Rebecca L Read, John F Thompson
May 11, 2018·Journal of Oncology Practice·David E Gyorki
Dec 15, 2018·Journal of Surgical Oncology·Jennifer M RaczJames W Jakub
Aug 14, 2019·Annals of Surgical Oncology·Amanda A G NijhuisOmgo E Nieweg
Aug 21, 2020·Scientific Reports·Vladimir SadkinRoman Zelchan
Jan 17, 2019·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Robyn D GartrellYvonne M Saenger
Oct 23, 2019·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Prathamesh M KulkarniYvonne M Saenger
Nov 22, 2020·European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·Ilaria MattavelliMario Santinami

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