Sentinel Lymph Node Biopsy in Breast Cancer Patients by Means of Indocyanine Green Using the Karl Storz VITOM® Fluorescence Camera

BioMed Research International
Thomas PapathemelisSophia Scharl

Abstract

Currently, the use of radioisotope and blue dye for sentinel lymph node biopsy (SLNB) for axillary staging in breast cancer is common. Recently, indocyanine green (ICG) has been proposed as an alternative sentinel lymph node (SLN) tracking agent. We evaluated the clinical value of ICG as an additional tracer in combination with Technetium99m and as an alternative to Technetium99m for the identification of SLN in 104 breast cancer patients. 21 patients had at least 1 histologically tumor-positive SLN. All 21 patients were detected by ICG; in one of these 21 sentinel-positive patients, Technetium99m was unable to identify lymph node involvement. Our results show that ICG is as effective as the radioisotope for SLNB. In addition, as a near-infrared dye, it has the advantages of real-time visualization, lower cost, and wider availability, since no radioactive material needs to be handled. This trial is registered with German Clinical Trial Register Main ID: DRKS00013606.

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Citations

Aug 14, 2019·The Korean Journal of Thoracic and Cardiovascular Surgery·Priyanka DasHak Soo Choi
Jan 29, 2020·The Breast Journal·Sarah FranciniMartha Duraes
Apr 17, 2020·The Laryngoscope·Armando De VirgilioGiuseppe Spriano
Oct 12, 2021·European Journal of Nuclear Medicine and Molecular Imaging·H M SchouwS Kruijff
Dec 31, 2021·The Annals of Otology, Rhinology, and Laryngology·Armando De VirgilioGiuseppe Spriano

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Methods Mentioned

BETA
biopsy
dissection

Software Mentioned

SPSS Statistics

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