Sentinel Lymph Node Biopsy in Vulvar Cancer Using Combined Radioactive and Fluorescence Guidance

International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society
Floris P R VerbeekAlexander L Vahrmeijer

Abstract

Near-infrared (NIR) fluorescence imaging using indocyanine green (ICG) has recently been introduced to improve the sentinel lymph node (SLN) procedure. Several optical tracers have been successfully tested. However, the optimal tracer formulation is still unknown. This study evaluates the performance of ICG-technetium-99m (99mTc)-nanocolloid in relation to 2 most commonly used ICG-based formulas during SLN biopsy in vulvar cancer. Twelve women who planned to undergo SLN biopsy for stage I vulvar cancer were prospectively included. Sentinel lymph node mapping was performed using the dual-modality radioactive and NIR fluorescence tracer ICG-99mTc-nanocolloid. All patients underwent combined SLN localization using NIR fluorescence and the (current) gold standard using blue dye and radioactive guidance. In all 12 patients, at least 1 SLN was detected during surgery. A total of 21 lymph nodes (median 2; range, 1-3) were resected. Median time between skin incision and first SLN detection was 8 (range, 1-22) minutes. All resected SLNs were both radioactive and fluorescent, although only 13 (62%) of 21 SLNs stained blue. Median brightness of exposed SLNs, expressed as signal-to-background ratio, was 5.4 (range, 1.8-11.8). Lymph node me...Continue Reading

References

Jul 18, 2001·Annals of Surgical Oncology·O E NiewegB B Kroon
Aug 25, 2001·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·A P MakarC G Tropé
Nov 19, 2002·Cancer·Joanne A De HulluAte G J Van Der Zee
Mar 22, 2003·Journal of the American College of Surgeons·Roman RouzierBernard-Jean Paniel
Aug 13, 2003·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·K N GaarenstroomI Vergote
Dec 13, 2006·International Journal of Gynaecology and Obstetrics : the Official Organ of the International Federation of Gynaecology and Obstetrics·U BellerA P M Heintz
Feb 19, 2008·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Ate G J Van der ZeeWim J Sluiter
Nov 20, 2009·Gynecologic Oncology·Jakub RadziszewskiJanusz A Siedlecki
Apr 13, 2011·The British Journal of Surgery·A L Vahrmeijer, J V Frangioni
Apr 16, 2011·Journal of Surgical Oncology·Boudewijn E SchaafsmaAlexander L Vahrmeijer
Oct 27, 2011·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·Joost R van der VorstAlexander L Vahrmeijer
Feb 20, 2013·BJOG : an International Journal of Obstetrics and Gynaecology·B E SchaafsmaK N Gaarenstroom
May 23, 2013·The British Journal of Surgery·B E SchaafsmaA L Vahrmeijer
Jul 25, 2013·Nature Reviews. Clinical Oncology·Alexander L VahrmeijerJohn V Frangioni
Sep 21, 2013·Gynecologic Oncology·H M MathéronR A Valdés Olmos
Dec 18, 2013·Breast Cancer Research and Treatment·Floris P R VerbeekJohn V Frangioni
Sep 5, 2014·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·Britt K EricksonJ Michael Straughn
Nov 1, 2006·International Journal of Gynaecology and Obstetrics : the Official Organ of the International Federation of Gynaecology and Obstetrics·U BellerApm Heintz

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Citations

Mar 5, 2016·The British Journal of Radiology·Fijs W B van LeeuwenSergi Vidal-Sicart
Apr 12, 2017·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·Philipp SoergelPeter Hillemanns
Nov 11, 2017·Future Oncology·Henri AzaïsSerge Mordon
Dec 28, 2018·Plastic and Reconstructive Surgery·Dhruv SinghalSamuel J Lin
Aug 2, 2017·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·Mark R Brincat, Yves Muscat Baron
Jan 4, 2020·European Journal of Nuclear Medicine and Molecular Imaging·Angela CollarinoMarco Maccauro
May 20, 2020·Journal of Biomaterials Applications·Qi FanBo Peng
Aug 15, 2017·Clinical and Translational Imaging : Reviews in Nuclear Medicine and Molecular Imaging·S L BugbyA C Perkins
Jan 19, 2018·Oncology Letters·Jiang DuQiling Li
Jun 13, 2019·Nanophotonics·Salar SajediHak Soo Choi
Feb 15, 2020·Archives of Gynecology and Obstetrics·Sonia PraderBeyhan Ataseven
Jan 18, 2017·Nature Reviews. Clinical Oncology·Ray R ZhangJamey P Weichert
May 12, 2017·European Journal of Nuclear Medicine and Molecular Imaging·Pilar ParedesFrancisco Lomeña
Oct 31, 2017·Journal of Surgical Oncology·Heman M JoshiManish Chand
Mar 20, 2018·Techniques in Coloproctology·M ChandR Cohen
May 31, 2018·Molecular Imaging and Biology : MIB : the Official Publication of the Academy of Molecular Imaging·Charlotte HoogstinsJacobus Burggraaf
Sep 23, 2020·Radiology and Oncology·Sebastjan Merlo
Apr 23, 2016·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Marlène C H HekmanMark Rijpkema
Jul 6, 2020·European Journal of Obstetrics, Gynecology, and Reproductive Biology·Jo MorrisonChristina Fotopoulou
Mar 23, 2019·Bulletin du cancer·Henri AzaïsUNKNOWN Groupe transversal sein-gynécologie AP–HP
Nov 3, 2016·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Travis M ShafferJan Grimm
Jan 28, 2017·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Marlène C H HekmanOtto C Boerman
Jul 28, 2021·Revista Española De Medicina Nuclear E Imagen Molecular·Pilar Paredes, Berta Díaz-Feijoo
Jul 28, 2021·Revista española de medicina nuclear e imagen molecular·P Paredes, B Díaz-Feijoo

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