Sentinel lymph node detection in primary melanoma with preoperative dynamic lymphoscintigraphy and intraoperative gamma probe guidance

The British Journal of Surgery
Olivier TiffetF Cambazard

Abstract

This study assessed the value of the radioisotopic method used alone, and factors influencing relapse rates, for sentinel lymph node (SLN) mapping in primary melanoma. One hundred and thirty-three patients with a diagnosis of melanoma (thickness greater than 0.75 mm) underwent gamma probe-directed lymphatic mapping in a prospective single-centre study. Mean Breslow thickness was 3 mm. At least one SLN was identified in 132 patients (mean 1.8 nodes per patient); the success rate was 99.2 per cent. Twenty-two patients (16.7 per cent) had a metastasis within the SLN. The mean tumour thickness in patients with a metastatic SLN was 4.4 mm compared with 2.7 mm for patients with a negative SLN (P < 0.001). The median time to recurrence was 20.4 months in SLN-negative patients compared with 8.5 months in those with SLN metastasis (P < 0.001). Ten (9.1 per cent) of the 110 SLN-negative patients developed recurrence. Three patients relapsed in the previously mapped lymphatic basin after a median follow-up of 27.1 months. This study confirmed the reliability and accuracy of SLN mapping using a radioisotope technique, and also the importance of the SLN as a predictive factor for survival. There was a low risk of locoregional recurrence whe...Continue Reading

References

Sep 22, 1977·The New England Journal of Medicine·U VeronesiN N Trapeznikov
Apr 1, 1992·Archives of Surgery·D L MortonA J Cochran
Jul 18, 1991·The New England Journal of Medicine·H K Koh
Apr 1, 1991·Archives of Surgery·U Veronesi, N Cascinelli
May 5, 1988·The New England Journal of Medicine·U VeronesiJ C Durand
Jun 1, 1995·Archives of Surgery·D N KragJ C Alex
Dec 1, 1994·The British Journal of Surgery·H van der VeenS Meijer
Oct 1, 1993·Surgical Oncology·J C AlexD N Krag
Jan 1, 1996·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·J M KirkwoodR H Blum
Jun 1, 1997·Archives of Surgery·S P LeongR W Sagebiel
Nov 28, 1997·American Journal of Surgery·P BostickD Morton
Apr 12, 2000·The British Journal of Surgery·L JansenB B Kroon
Jun 22, 2002·Dermatology : International Journal for Clinical and Investigative Dermatology·T BelhocineP Rigo
Sep 26, 2002·World Journal of Surgery·Markwin G Statius MullerSybren Meijer
Jan 7, 2003·Archives of Surgery·Ira A JacobsGeorge Salti

❮ Previous
Next ❯

Citations

Sep 5, 2008·Nuclear Medicine Communications·Ivan A Ho ShonJohn F Thompson
Aug 10, 2005·American Journal of Clinical Pathology·Laura E StewartRobin T Vollmer
Mar 9, 2011·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Matias E ValsecchiGary H Lyman
Nov 29, 2016·Dermatologic Surgery : Official Publication for American Society for Dermatologic Surgery [et Al.]·Nathalie Pham DangIsabelle Barthélémy
Oct 23, 2008·Acta Oncologica·Jan MattssonChristian Ingvar
May 18, 2006·Journal of Surgical Oncology·Edwina H DotingHarald J Hoekstra
Aug 16, 2015·American Journal of Clinical Pathology·Robin T Vollmer
May 22, 2010·The Journal of Pharmacy and Pharmacology·Firuz CelikogluEugene P Goldberg
May 28, 2016·Melanoma Research·Iris M C van der PloegAlexander J C van Akkooi

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.