Sentinel lymph nodes for breast carcinoma: an update on current practice

Histopathology
Aoife Maguire, E Brogi

Abstract

Sentinel lymph node (SLN) biopsy has been established as the standard of care for axillary staging in patients with invasive breast carcinoma and clinically negative lymph nodes (cN0). Historically, all patients with a positive SLN underwent axillary lymph node dissection (ALND). The ACOSOG Z0011 trial showed that women with T1-T2 disease and cN0 who undergo breast-conserving surgery and whole-breast radiotherapy can safely avoid ALND. The main goal of SLN examination should be to detect all macrometastases (>2 mm). Gross sectioning of SLNs at 2-mm intervals and microscopic examination of one haematoxylin and eosin-stained section from each SLN block is the preferred method for pathological evaluation of SLNs. The role and timing of SLN biopsy for patients who have received neoadjuvant chemotherapy is controversial, and continues to be explored in clinical trials. SLN biopsies from patients with invasive breast carcinoma who have received neoadjuvant chemotherapy pose particular challenges for pathologists.

References

Jul 1, 1995·The British Journal of Surgery·M A Potter, A M Thompson
Mar 1, 1995·The British Journal of Surgery·A Recht
Sep 1, 1994·The British Journal of Surgery·S J Falk
Sep 1, 1994·Annals of Surgery·A E GiulianoD L Morton
Dec 11, 1996·JAMA : the Journal of the American Medical Association·J J AlbertiniD S Reintgen
Jun 1, 1997·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·A E GiulianoR Statman
Mar 24, 1998·Journal of the American College of Surgeons·P J BorgsteinS Meijer
Oct 1, 1998·The New England Journal of Medicine·D KragP Beitsch
Nov 16, 2001·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·J A van der HageL Duchateau
Nov 16, 2002·American Journal of Surgery·Stephen A ShiverEdward A Levine
Mar 27, 2003·The American Journal of Surgical Pathology·Eugenio MaioranoGiuseppe Viale
May 27, 2003·The American Journal of Surgical Pathology·Donald L Weaver
Jul 30, 2003·American Journal of Surgery·Michael S SabelLori J Pierce
Aug 9, 2003·The New England Journal of Medicine·Umberto VeronesiRoberto Gennari
Oct 16, 2003·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Harry D BearUNKNOWN National Surgical Adjuvant Breast and Bowel Project Protocol B-27
Feb 5, 2004·The Breast : Official Journal of the European Society of Mastology·S HolckJ Hoffmann
Feb 18, 2004·The Breast : Official Journal of the European Society of Mastology·L BarthelmesD J Crawford
Feb 3, 2005·Journal of the National Cancer Institute·Davide MauriJohn P A Ioannidis
Apr 20, 2005·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Eleftherios P MamounasNorman Wolmark
Aug 18, 2005·The British Journal of Surgery·K TewP Macaskill
Sep 15, 2005·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Gary H LymanUNKNOWN American Society of Clinical Oncology
Dec 20, 2005·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Bryan T HennessyVicente Valero
Feb 2, 2006·CA: a Cancer Journal for Clinicians·S Eva Singletary, James L Connolly
Mar 22, 2006·The British Journal of Surgery·D W ChickenM R S Keshtgar
May 18, 2006·Journal of Surgical Oncology·Angela KatzColette Magnant

❮ Previous
Next ❯

Citations

Aug 9, 2016·The Surgeon : Journal of the Royal Colleges of Surgeons of Edinburgh and Ireland·Kalnisha Naidoo, Sarah E Pinder
Jul 16, 2019·Expert Opinion on Drug Safety·Sherif Hassanien Ahmed
Feb 26, 2019·Technology in Cancer Research & Treatment·Willard WongFang-I Lu
Aug 25, 2020·Mayo Clinic Proceedings·Oscar J ManriqueHung-Chi Chen
Apr 15, 2021·Expert Review of Anticancer Therapy·Alessandra FozzaAntonella Ciabattoni
Nov 20, 2020·Archives of Pathology & Laboratory Medicine·Rebecca CzajaJulie M Jorns
Mar 12, 2021·Acta Cytologica·Jose Antonio Jimenez-HeffernanConsuelo López-Elzaurdia

❮ Previous
Next ❯

Related Concepts

Related Feeds

Breast Invasive Carcinoma

Invasive breast cancers indicate a spread into breast tissues and lymph nodes. Here are the latest discoveries pertaining to breast invasive carcinomas.

Carcinoma, Ductal

Ductal carcinoma is a malignant neoplasm involving the ductal systems of any of a number of organs, such as the mammary glands, pancreas, prostate or lacrimal gland. Discover the latest research on ductal carcinoma here.

Breast Invasive Carcinoma (Keystone)

Invasive breast cancers indicate a spread into breast tissues and lymph nodes. Here are the latest discoveries pertaining to breast invasive carcinomas.

Related Papers

Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology
Reshma JagsiBruce G Haffty
Breast Cancer : the Journal of the Japanese Breast Cancer Society
Masakuni NoguchiTakeo Kosaka
Cancer Control : Journal of the Moffitt Cancer Center
Miraj Shah-Khan, Judy C Boughey
© 2022 Meta ULC. All rights reserved