PMID: 9527265Apr 4, 1998Paper

Sentinel node biopsy in breast cancer

Annals of Surgical Oncology
J M BarnwellS B Edge

Abstract

Sentinel lymph node biopsy (SNB) in breast cancer may be used in place of axillary lymph node dissection (ALND) if SNB accurately stages the axilla. This study assessed the success and accuracy of axillary SNB with isosulfan blue (ISB) and technetium-99 sulfur colloid (TSC) compared to ALND. Forty-two women with T1 or T2 breast cancer underwent SNB and ALND. Sixty to 90 minutes before anesthetic induction, a mixture of 3 mL ISB and 1 mCi TSC was injected around the primary cancer or prior biopsy site. Intraoperatively, the SLN was identified using a gamma detector (Neoprobe 1000) or by visualization of the blue-stained lymph node and afferent lymphatics. The SLN was excised separately, and a level I/II ALND was completed. The histologic findings of the axillary contents and SLN were compared. An axillary SLN was found in 38 of 42 (90%) cases. SLN localization rate and predictive value were the same for women who had and those who had not undergone excisional biopsy before the date of SNB. Fifteen of 42 (36%) patients had lymph node metastases. The SLN was positive in all women with axillary metastases (negative predictive value, 100%). If confirmed by larger series, a negative SNB may eliminate the need for ALND for select wome...Continue Reading

References

Apr 1, 1992·Archives of Surgery·D L MortonA J Cochran
Jan 1, 1988·International Journal of Radiation Applications and Instrumentation. Part B, Nuclear Medicine and Biology·R L WahlN A Petry
Jun 1, 1995·Archives of Surgery·D N KragJ C Alex
Sep 1, 1995·Annals of Surgery·A E GiulianoD L Krasne
Dec 7, 1994·Journal of the National Cancer Institute·P M RavdinG M Clark
Sep 1, 1994·Annals of Surgery·A E GiulianoD L Morton
Apr 1, 1993·The British Journal of Surgery·P J HainsworthR C Bennett
Jan 1, 1996·British Journal of Cancer·M A McGuckinR G Wright
Nov 1, 1995·Cancer·A Recht, M J Houlihan
May 1, 1996·Annals of Surgical Oncology·M Morrow
Jan 1, 1996·Breast Cancer Research and Treatment·P L ChoongY Attikiouzel
Jan 1, 1996·Breast Cancer Research and Treatment·M NoguchiI Miyazaki
Mar 1, 1997·Annals of Surgical Oncology·S D NathansonS Havstad

❮ Previous
Next ❯

Citations

Aug 28, 2001·Seminars in Surgical Oncology·I T Rubio, V S Klimberg
Mar 29, 2002·Journal of Surgical Oncology·David M EuhusJames Huth
Oct 16, 2003·Journal of the National Cancer Institute·Stephen B EdgeJane C Weeks
Dec 3, 2005·Breast Cancer Research and Treatment·V OzmenA Mudun
Jul 29, 2008·World Journal of Surgical Oncology·Margaret I Liang, William E Carson
Apr 4, 2009·Vojnosanitetski pregled. Military-medical and pharmaceutical review·Milan VisnjićGoran Dordević
Nov 24, 1999·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·C ReynoldsB J Czerniecki
Aug 15, 2000·Cancer Biotherapy & Radiopharmaceuticals·S S JeffreyK L Smith
Feb 24, 2001·Annals of Surgical Oncology·S K BoolbolK J Van Zee
Apr 12, 2000·Cancer Control : Journal of the Moffitt Cancer Center·P I HaighA E Giuliano
Mar 10, 2001·Nuclear Medicine Communications·Y KrauszH W Strauss
Jul 9, 2002·The Breast Journal·Sandra L WongKelly M McMasters
Dec 22, 2004·Current Oncology Reports·Lori L Wilson, Armando E Giuliano
Oct 9, 2008·Breast Cancer : the Journal of the Japanese Breast Cancer Society·H S Cody
Sep 3, 2010·The British Journal of Surgery·D M LayfieldR I Cutress
Oct 13, 2000·Breast Cancer : the Journal of the Japanese Breast Cancer Society·E E Zervos, W E Burak
Mar 16, 2001·Breast Cancer Research : BCR·H S Cody
Oct 1, 1998·The New England Journal of Medicine·K M McMastersM J Edwards
Oct 13, 2000·Breast Cancer : the Journal of the Japanese Breast Cancer Society·S P LeongJ H Wong
Nov 25, 2000·Breast Cancer : the Journal of the Japanese Breast Cancer Society·P I HaighA E Giuliano
Mar 30, 2002·Annals of Surgical Oncology·Sandra L WongUNKNOWN University of Louisville Breast Cancer Study Group
Sep 26, 2002·World Journal of Surgery·Jyh-Cherng YuTsu-Yi Chao
May 6, 2004·The Breast Journal·David J Dabbs, Ronald Johnson
Mar 3, 2004·Journal of Surgical Oncology·Marco GipponiFerdinando Cafiero

❮ Previous
Next ❯

Related Concepts

Related Feeds

Breast Invasive Carcinoma

Invasive breast cancers indicate a spread into breast tissues and lymph nodes. Here are the latest discoveries pertaining to breast invasive carcinomas.

Breast Invasive Carcinoma (Keystone)

Invasive breast cancers indicate a spread into breast tissues and lymph nodes. Here are the latest discoveries pertaining to breast invasive carcinomas.

CSF & Lymphatic System

This feed focuses on Cerebral Spinal Fluid (CSF) and the lymphatic system. Discover the latest papers using imaging techniques to track CSF outflow into the lymphatic system in animal models.