Sentinel node navigation surgery using near-infrared indocyanine green fluorescence in early gastric cancer.

Surgical Endoscopy
Dong-Wook KimHyung-Ho Kim

Abstract

The aim of this study was to evaluate the feasibility of indocyanine green (ICG) fluorescent method for sentinel lymph node detection in early gastric cancer. Between December 2012 and December 2014, 28 cases of pilot examination were performed at Seoul National University Bundang Hospital. Advanced version of multispectral fluorescence organoscope was used to identify sentinel node by quantitative estimation of ICG fluorescent signal intensity. Sensitivity, specificity, false positive value were analyzed and compared with dual tracer method. A total of 443 lymph nodes in 28 cases were examined and 184 sentinel nodes (41.5%) were identified by dual tracer method. The sensitivity using near-infrared ICG method was 98.9%. The specificity was 76.0% and false positive rate was 25.4% compared with dual tracer method. The adequate threshold for sentinel node detection was considered as 10% of maximum signal intensity. New near-infrared ICG fluorescent method could be a promising protocol for sentinel node navigation surgery in early gastric cancer.

References

Mar 1, 1995·The British Journal of Surgery·M SasakoK Maruyama
Jan 5, 2001·The Surgical Clinics of North America·Y KitagawaM Kitajima
May 2, 2002·Gastric Cancer : Official Journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association·Takuji GotodaYo Kato
Jan 9, 2003·Journal of the American College of Surgeons·Hideki HayashiHideaki Shimada
Jan 30, 2003·The British Journal of Surgery·K MiwaA Nonomura
Dec 9, 2003·Nature Biotechnology·Sungjee KimJohn V Frangioni
Jan 26, 2007·Scandinavian Journal of Surgery : SJS : Official Organ for the Finnish Surgical Society and the Scandinavian Surgical Society·Y KitagawaM Kitajima
Mar 5, 2008·Journal of Biomedicine & Biotechnology·Arthur M IgaAlexander M Seifalian
Oct 1, 2010·Annals of Surgical Oncology·Kay Washington
Apr 18, 2012·Journal of Gastroenterology and Hepatology·Masashi YoshidaMasaki Kitajima
Sep 4, 2012·Annals of Surgical Oncology·Hiroya Takeuchi, Yuko Kitagawa
Sep 11, 2013·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Yuko KitagawaMasaki Kitajima
Jan 28, 2014·Biomedical Optics Express·Funda Meric-BernstamEva M Sevick-Muraca
Feb 1, 2014·Gastric Cancer : Official Journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association·Seong-Ho KongHan-Kwang Yang
Jun 11, 2014·World Journal of Gastroenterology : WJG·Norio MitsumoriKatsuhiko Yanaga
Jan 23, 2015·The Cancer Journal·Hiroya Takeuchi, Yuko Kitagawa
Jun 28, 2016·Gastric Cancer : Official Journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association·UNKNOWN Japanese Gastric Cancer Association
Oct 19, 2016·Journal of Gastric Cancer·UNKNOWN Information Committee of Korean Gastric Cancer Association
Apr 19, 2017·Gastric Cancer : Official Journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association·Hitoshi KataiUNKNOWN Registration Committee of the Japanese Gastric Cancer Association

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Citations

Sep 26, 2019·Der Chirurg; Zeitschrift für alle Gebiete der operativen Medizen·Andrea PicchettoMichele Diana
Jul 2, 2020·Updates in Surgery·Gian Luca BaiocchiFederico Gheza
Jan 4, 2021·Gastric Cancer : Official Journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association·Sang Il YounHyung-Ho Kim

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