Sentinel node positive breast cancer patients who do not undergo axillary dissection: are they different?

Surgery
Shaheen ZakariaAmy C Degnim

Abstract

Little data address outcome in patients with sentinel lymph node (SN) metastases without completion axillary lymph node dissection (CALND). This study was designed to assess locoregional recurrence in patients with positive SNs who did not undergo CALND. An IRB-approved, retrospective chart review was conducted on breast cancer patients with a positive SN. Follow-up information on outcomes was obtained via mailed questionnaires and chart review. Comparative analyses were performed between patients who did and did not undergo CALND after a positive sentinel lymph node biopsy. From November 1998 to June 2004, 625 breast cancer patients had a positive sentinel lymph node biopsy. One-hundred and eighteen patients with < or = 0.2 mm nodal metastases (N0i+) were excluded from the study. Of the remaining 507 patients, 421 underwent CALND and 86 did not. In comparison to patients who had CALND, patients who did not undergo CALND had smaller primary tumors (2 vs 2.6 cm, P = .0007) and were more likely to have a single positive sentinel node (92% vs 77%, P = .002). The metastasis size of the sentinel node was smaller compared to patients who underwent axillary dissection (1.7 vs 6.4 mm, P < .0001). Mean predicted probability of nonsentin...Continue Reading

References

Nov 30, 1995·The New England Journal of Medicine·UNKNOWN Early Breast Cancer Trialists' Collaborative Group
Sep 1, 1995·Annals of Surgery·A E GiulianoD L Krasne
Oct 1, 1998·The New England Journal of Medicine·D KragP Beitsch
Nov 20, 1998·Lancet·M Baum
Feb 28, 2001·Journal of the American College of Surgeons·S E Singletary
May 4, 2001·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·J M VerversA C Voogd
Jan 7, 2003·Archives of Surgery·J Michael GuentherTheodore X O'Connell
Aug 9, 2003·The New England Journal of Medicine·Umberto VeronesiRoberto Gennari
Mar 26, 2005·European Journal of Nuclear Medicine and Molecular Imaging·A SanjuànJ A Vanrell
Apr 14, 2005·Annals of Surgical Oncology·Philip Z Israel

❮ Previous
Next ❯

Citations

Aug 15, 2012·Annals of Surgical Oncology·Claire M T P FrancissenJohannes H W de Wilt
Dec 17, 2008·Current Oncology Reports·Kathleen M Erb, Thomas B Julian
Aug 25, 2009·Breast Cancer : the Journal of the Japanese Breast Cancer Society·Hiroyuki TakeiToshio Tabei
Aug 12, 2010·European Journal of Nuclear Medicine and Molecular Imaging·Gang ChengAbass Alavi
Mar 13, 2014·Asian Pacific Journal of Cancer Prevention : APJCP·Bulent KocaYuksel Bek
Dec 11, 2014·World Journal of Clinical Oncology·Can Atalay
Jul 14, 2010·Surgical Oncology Clinics of North America·Michael S Sabel

❮ Previous
Next ❯

Related Concepts

Related Feeds

Breast Invasive Carcinoma

Invasive breast cancers indicate a spread into breast tissues and lymph nodes. Here are the latest discoveries pertaining to breast invasive carcinomas.

Carcinoma, Lobular

Lobular carcinoma is an invasive type of breast cancer in which lobules, areas of the breast that produce milk, undergo malignant transformation. Here is the latest research.

Carcinoma, Ductal

Ductal carcinoma is a malignant neoplasm involving the ductal systems of any of a number of organs, such as the mammary glands, pancreas, prostate or lacrimal gland. Discover the latest research on ductal carcinoma here.

Breast Invasive Carcinoma (Keystone)

Invasive breast cancers indicate a spread into breast tissues and lymph nodes. Here are the latest discoveries pertaining to breast invasive carcinomas.