Separable roles of the nucleus accumbens core and shell in context- and cue-induced alcohol-seeking.

Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology
N ChaudhriP H Janak

Abstract

Conditioned responding to drug-predictive discrete cues can be strongly modulated by drug-associated contexts. We tested the hypothesis that differential recruitment of the nucleus accumbens (NAc) core and shell mediates responding to drug cues in a drug vs non-drug context. Rats were trained to discriminate between two 10-s auditory stimuli: one stimulus (CS+) was paired with ethanol (10% v/v; 0.2 ml; oral) whereas the other (CS-) was not. Training occurred in operant conditioning chambers distinguished by contextual stimuli, and resulted in increased entries into the ethanol delivery port during the CS+ when compared with the CS-. In experiment 1, port entries were then extinguished in a second context by withholding ethanol, after which context-induced renewal of ethanol-seeking was tested by presenting both stimuli without ethanol in the previous training context. This manipulation stimulated strong responding to the CS+ in rats pretreated with saline in the core (n=9) or shell (n=10), which was attenuated by pharmacologically inactivating (muscimol/baclofen; 0.1/1.0 mM; 0.3 microl/side) either subregion pretest. In experiment 2, after discrimination, training rats were habituated to a different context in which ethanol and...Continue Reading

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Jun 10, 2011·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Manoranjan S D'SouzaAthina Markou
Aug 2, 2013·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Daniela CassataroLucas Sjulson
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