Separate and combined effects of heat stress and exercise on circulatory markers of oxidative stress in euhydrated humans.

European Journal of Applied Physiology
Orlando LaitanoJosé González-Alonso

Abstract

Combined heat stress, dehydration, and exercise is associated with enhanced oxidative stress in humans, but the separate and combined effects of heat stress and exercise on circulatory markers of oxidative stress without the influence of dehydration remain uncertain. The purpose of this study was to determine the effects of whole body heat stress alone and in combination with exercise on blood markers of oxidative stress in euhydrated humans. Eight males wore a water-perfused suit at rest and during 6 min of one-legged knee extensor exercise under control and heat stress conditions while maintaining euhydration. Following the control trial and a 15 min resting period, hot water was perfused through the suit in order to increase core, skin, and mean body temperatures by ~1, ~6, and ~2°C, respectively. Blood samples were taken to measure reduced glutathione (GSH), oxidized glutathione (GSSG), superoxide dismutase (SOD) and plasma isoprostanes. Heat stress alone did not alter GSH, SOD activity, or plasma isoprostanes, but increased GSSG leading to a reduction in the GSH/GSSG ratio. No changes in these variables were observed with exercise alone. Conversely, combined heat stress and exercise increased both GSH and GSSG, decreased S...Continue Reading

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Citations

Oct 11, 2011·Applied Physiology, Nutrition, and Metabolism = Physiologie Appliquée, Nutrition Et Métabolisme·Angela R HillmanJason Siegler
May 27, 2016·Temperature : Multidisciplinary Biomedical Journal·Ana Angélica Souza-SilvaOrlando Laitano
Feb 10, 2017·Applied Physiology, Nutrition, and Metabolism = Physiologie Appliquée, Nutrition Et Métabolisme·Vincent P GeorgescuSteven R McAnulty
Nov 13, 2015·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Michelle A KingOrlando Laitano
Nov 16, 2018·Frontiers in Physiology·Orlando LaitanoThomas L Clanton
Mar 30, 2017·Temperature : Multidisciplinary Biomedical Journal·Ashley Paul AkermanJames David Cotter
Aug 24, 2021·Journal of Thermal Biology·Denise de Melo-MarinsAlvaro Reischak-Oliveira

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