PMID: 3987793Jan 1, 1985Paper

Separate and combined effects of nadolol and nifedipine on the cardiac response to exercise

European Journal of Clinical Pharmacology
M R WilkinsS J Laugher

Abstract

In a placebo controlled exercise protocol using healthy volunteers the effects of nadolol 80 mg and 160 mg orally and of nadolol 80 mg during treatment with nifedipine 20 mg 8 hourly were compared. Resting systolic and diastolic blood pressures were reduced by both nifedipine (p less than 0.05) and nadolol (p less than 0.01) acting alone. An unexpected finding was that nifedipine alone significantly inhibited exercise tachycardia (p less than 0.01) (8 to 12 h post dose). Predictably both doses of nadolol produced significant reduction in exercise tachycardia which was still apparent at 24 h. There was a linear relationship between log10 plasma nadolol concentration and reduction in exercise heart rate. The combined inhibitory effects of nifedipine and nadolol 80 mg on exercise heart rate showed partial additivity but did not summate. There was no pharmacokinetic interaction between the 2 drugs. The inhibition of exercise tachycardia by nifedipine, not previously documented, is consistent with an effect of the drug on the sinus node, as has been reported in in-vitro studies, and may contribute to the drugs efficacy in angina.

References

Jun 1, 1975·The Journal of Pharmacy and Pharmacology·B Scales, P B Copsey
Sep 17, 1981·The New England Journal of Medicine·W H Frishman
Jan 1, 1982·European Journal of Clinical Pharmacology·D B JackM J Kendall
Jan 1, 1982·Journal of Cardiovascular Pharmacology·G A MacGregorG A Sagnella
Dec 1, 1983·European Heart Journal·A FleckensteinG Fleckenstein-Grün
Oct 1, 1981·The American Journal of Medicine·H J DargieS Krikler
Oct 1, 1982·The American Journal of Cardiology·M D WinnifordL D Hillis

Citations

Jan 1, 1987·European Journal of Clinical Pharmacology·S R SmithS J Laugher
Jan 1, 1988·Fundamental & Clinical Pharmacology·E Zylber-KatzM Levy

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