Separate and combined effects of recombinant interleukin-1 alpha and gamma interferon on antibacterial resistance.

Infection and Immunity
R S KurtzC J Czuprynski

Abstract

Our laboratory has previously reported that administration of murine recombinant interleukin 1 alpha (rIL-1 alpha) substantially enhanced the resistance of mice to Listeria monocytogenes infection. Other investigators have reported that gamma interferon (IFN-gamma) plays a pivotal role in antilisteria resistance. In the present study, we have defined doses of human rIL-1 alpha that enhanced the antilisteria resistance of mice. We then addressed the possibility that combined immunotherapy with rIL-1 alpha and recombinant IFN-gamma (rIFN-gamma) might result in an additive or synergistic enhancement of antibacterial resistance. Simultaneous administration of rIL-1 alpha and rIFN-gamma enhanced antilisteria resistance (at 3 days after infection) to a greater extent than did either cytokine alone, although the results did not imply a synergistic action between the two cytokines. Experiments which examined the effects of the timing of cytokine administration indicated that maximal protection was observed when rIL-1 alpha and rIFN-gamma were administered together concomitantly with the L. monocytogenes challenge. When we compared the separate and combined protective effects of rIL-1 alpha and rIFN-gamma throughout the course of a prim...Continue Reading

References

May 1, 1986·The Journal of Infectious Diseases·E A Havell
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Citations

Jan 1, 1993·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·C W Czarniecki, G Sonnenfeld
Jun 1, 1993·International Journal of Dermatology·S P Raychaudhuri, S K Raychaudhuri
Sep 1, 1993·Agents and Actions·S HockertzT Schettler
Sep 1, 1992·American Journal of Respiratory Cell and Molecular Biology·P S TobiasR J Ulevitch
Jan 1, 1994·Biotherapy·B J Kullberg, J W van 't Wout
Jan 22, 2004·BioDrugs : Clinical Immunotherapeutics, Biopharmaceuticals and Gene Therapy·Mihai G NeteaJos W M Van der Meer
Nov 1, 1993·Immunobiology·M E MielkeH Hahn

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