Separating fetal and maternal placenta circulations using multiparametric MRI

Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine
Andrew MelbourneSebastien Ourselin

Abstract

The placenta is a vital organ for the exchange of oxygen, nutrients, and waste products between fetus and mother. The placenta may suffer from several pathologies, which affect this fetal-maternal exchange, thus the flow properties of the placenta are of interest in determining the course of pregnancy. In this work, we propose a new multiparametric model for placental tissue signal in MRI. We describe a method that separates fetal and maternal flow characteristics of the placenta using a 3-compartment model comprising fast and slowly circulating fluid pools, and a tissue pool is fitted to overlapping multiecho T2 relaxometry and diffusion MRI with low b-values. We implemented the combined model and acquisition on a standard 1.5 Tesla clinical system with acquisition taking less than 20 minutes. We apply this combined acquisition in 6 control singleton placentas. Mean myometrial T2 relaxation time was 123.63 (±6.71) ms. Mean T2 relaxation time of maternal blood was 202.17 (±92.98) ms. In the placenta, mean T2 relaxation time of the fetal blood component was 144.89 (±54.42) ms. Mean ratio of maternal to fetal blood volume was 1.16 (±0.6), and mean fetal blood saturation was 72.93 (±20.11)% across all 6 cases. The novel acquisitio...Continue Reading

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Citations

Mar 19, 2019·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Paddy J SlatorDaniel C Alexander
Jul 16, 2019·Prenatal Diagnosis·Rosalind AughwaneAndrew Melbourne
Oct 9, 2019·Topics in Magnetic Resonance Imaging : TMRI·Daan ChristiaensJana Hutter
Oct 9, 2019·Topics in Magnetic Resonance Imaging : TMRI·Esra Abaci TurkP Ellen Grant
Aug 23, 2019·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Jana HutterEnrico De Vita
May 7, 2020·The Journal of Physiology·Brahmdeep S SainiMike Seed
Jul 1, 2020·BJOG : an International Journal of Obstetrics and Gynaecology·R AughwaneA Melbourne
May 29, 2020·PLoS Biology·Neele S DellschaftPenny A Gowland
Jul 29, 2020·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Ling JiangDan Wu
Mar 16, 2021·The Lancet Child & Adolescent Health·Joseph R DavidsonMary A Rutherford
Mar 7, 2021·The Journal of Physiology·Brahmdeep S SainiMike Seed
Jul 31, 2021·Placenta·Vijayalakshmi SrinivasanAlys R Clark
Jul 17, 2021·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Jana HutterMary A Rutherford
Aug 20, 2021·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Paddy J SlatorJana Hutter
Aug 15, 2021·Developmental Cognitive Neuroscience·Vidya RajagopalanMoriah E Thomason
Sep 26, 2021·Experimental Neurology·Nickie Andescavage, Catherine Limperopoulos

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Methods Mentioned

BETA
SGA

Software Mentioned

DECIDE
SNAP
itk
IVIM
ASL
MATLAB

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