Separating neural and vascular effects of caffeine using simultaneous EEG-FMRI: differential effects of caffeine on cognitive and sensorimotor brain responses.

NeuroImage
Ana DiukovaRichard G Wise

Abstract

The effects of caffeine are mediated through its non-selective antagonistic effects on adenosine A(1) and A(2A) adenosine receptors resulting in increased neuronal activity but also vasoconstriction in the brain. Caffeine, therefore, can modify BOLD FMRI signal responses through both its neural and its vascular effects depending on receptor distributions in different brain regions. In this study we aim to distinguish neural and vascular influences of a single dose of caffeine in measurements of task-related brain activity using simultaneous EEG-FMRI. We chose to compare low-level visual and motor (paced finger tapping) tasks with a cognitive (auditory oddball) task, with the expectation that caffeine would differentially affect brain responses in relation to these tasks. To avoid the influence of chronic caffeine intake, we examined the effect of 250 mg of oral caffeine on 14 non and infrequent caffeine consumers in a double-blind placebo-controlled cross-over study. Our results show that the task-related BOLD signal change in visual and primary motor cortex was significantly reduced by caffeine, while the amplitude and latency of visual evoked potentials over occipital cortex remained unaltered. However, during the auditory od...Continue Reading

References

Sep 1, 1991·Electroencephalography and Clinical Neurophysiology·P StanzioneG Amabile
Nov 1, 1995·Pharmacology, Biochemistry, and Behavior·J L Kenemans, M M Lorist
Oct 1, 1995·British Journal of Clinical Pharmacology·O AzconaF Jané
Aug 1, 1996·Psychiatry and Clinical Neurosciences·N KawamuraY Nakazawa
May 15, 1998·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·E C WongL R Frank
May 8, 1999·Journal of Magnetic Resonance Imaging : JMRI·J P WansapuraW S Ball
Jun 5, 1999·Reviews in the Neurosciences·C S CarterJ D Cohen
Oct 12, 2000·International Journal of Psychophysiology : Official Journal of the International Organization of Psychophysiology·J Polich, K L Herbst
Nov 25, 2000·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·J RuijterM M Lorist
Dec 9, 2000·Naunyn-Schmiedeberg's Archives of Pharmacology·H L Haas, O Selbach
Aug 23, 2001·Medical Image Analysis·M Jenkinson, S Smith
Jan 5, 2002·NeuroImage·Todd A MulderinkTodd B Parrish
Dec 5, 2002·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·Seppo KähkönenIiro P Jääskeläinen
Jul 5, 2003·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Gregory G BrownRichard B Buxton
Oct 22, 2003·NeuroImage·Christian F BeckmannStephen M Smith
Nov 15, 2003·Journal of Cognitive Neuroscience·Natalia S LawrenceElliot A Stein
Nov 15, 2003·Cerebral Cortex·Taosheng LiuSteven Yantis
Mar 31, 2004·NeuroImage·Mark W WoolrichStephen M Smith
Dec 14, 2004·NeuroImage·Thomas T LiuRichard B Buxton
Jul 12, 2005·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·A C DeslandesP Ribeiro
Aug 2, 2005·Arquivos de neuro-psiquiatria·Mariana MontenegroPedro Ribeiro
Oct 14, 2005·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·Robert J BarryIlinka Zlojutro
Dec 28, 2006·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Min QiaoUrsula I Tuor
Feb 14, 2007·Human Brain Mapping·Christian-G BénarJean-Luc Anton
Jun 19, 2007·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·John Polich
Oct 2, 2007·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·Robert J BarryDavid N McKenzie
Oct 16, 2007·NeuroImage·F KoppelstaetterB J Krause
Dec 20, 2007·Journal of Neurochemistry·Sergi Ferré
Mar 18, 2009·NeuroImage·Yufen Chen, Todd B Parrish
Jun 4, 2010·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Peter J RogersDavid J Nutt

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Citations

Sep 10, 2014·Neuroreport·Ying Wei WuXiaofeng Tao
Jul 17, 2014·Current Opinion in Supportive and Palliative Care·Kyle T S Pattinson, Miriam J Johnson
Nov 16, 2013·British Journal of Anaesthesia·K T S Pattinson
May 23, 2015·Frontiers in Neuroscience·Julius H Bourke, Matthew B Wall
Dec 1, 2012·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·Alan GevinsLita Sam-Vargas
Dec 19, 2013·The International Journal of Neuropsychopharmacology·R L Carhart-HarrisD J Nutt
Jul 9, 2014·Frontiers in Neuroscience·Hongjing XiaMark S Cohen
Jan 26, 2017·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·Andreas G FrankeKlaus Lieb
May 15, 2013·Cephalalgia : an International Journal of Headache·Delphine MagisGianluca Coppola
Apr 14, 2018·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Nilufer YalcinKatharina Eikermann-Haerter
May 13, 2018·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Georg OeltzschnerHans-Jörg Wittsack
Dec 24, 2017·Psychopharmacology·Christopher W N SavilleC Klein
Jan 23, 2018·Frontiers in Pharmacology·Amber KerkhofsHuibert D Mansvelder
Apr 24, 2021·Nutritional Neuroscience·Mansoureh Adel GhahramanElham Tavanai
Oct 14, 2021·Brain Topography·Anna E M ForsythSuresh D Muthukumaraswamy

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