PMID: 9433755Jan 20, 1998Paper

Separating spatially distributed response to stimulation from background. I. Optical imaging

Biological cybernetics
R M EversonL Sirovich

Abstract

We consider the problem of estimating a small stimulus-induced response to stimulation that is masked by a fluctuating background when measurements of the background in the absence of stimulation are available, as is common in optical imaging of the cortex and in many other experimental situations. Two related methods based on the Karhunen-Loève procedure are discussed. One seeks the function, an indicator function, that is most parallel to the response data and most orthogonal to the background data. The second removes the subspace spanned by the background from the response. Numerical investigations on simulated optical imaging data show that the first method is generally superior. Connections between the two methods and techniques for assessing the quality of the result are discussed.

Citations

Apr 2, 2003·NeuroImage·A SornborgerL Sirovich
Jul 8, 1998·Proceedings of the National Academy of Sciences of the United States of America·R M EversonE Kaplan
Dec 3, 2005·Journal of Neuroscience Methods·Jérôme RibotAyako Ajima
May 18, 2010·NeuroImage·Jakob H MackeMatthias Bethge
Jun 3, 2017·Neurophotonics·Sandrine ChemlaFrédéric Chavane

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