Jan 1, 1989

Separation and evaluation of changing pattern of glycosaminoglycans in 3-methyl cholanthrene induced fibrosarcoma

Neoplasma
R AsokanS C Dhar

Abstract

The present study evaluates the glycosaminoglycans (GAGs) pattern associated with transplantable rat fibrosarcoma induced by 3-methylcholanthrene. The quantitative analysis of fractionation of GAGs in fibrosarcoma and fetal tissues was performed by enzymatic digestion. The average value of total GAGs in fibrosarcoma and fetal tissue was found to be 4 times higher than its value in the tissue of origin. GAG content showed a steady increase from 7th day onward to 25th day. Hyaluronic acid content in tumor tissue was observed to increase markedly (8-fold) against that of the normal tissue and was equivalent to that of the fetal tissue. Chondroitin sulfate level was also increased in the tumor as well as fetal tissue. The increase in the chondroitin sulfate and hyaluronic acid contents might possibly be due to the abnormal GAG metabolism in the increased production of both sulfated and nonsulfated GAGs.

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Mentioned in this Paper

Metabolic Process, Cellular
20-Methylcholanthrene
Chondroitin Sulfate, Zinc Salt
Fetal Structures
Glycosaminoglycans
Tumor Tissue Sample
Rat Fibrosarcoma
Hyaluronic Acid Test
August Rats
Methylcholanthrene

About this Paper

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