Separation of drugs by high-performance liquid chromatography with porous polymer resins

Journal of Chromatography
R MatsudaN Takai

Abstract

The separation of cold drugs and neuroleptics by high-performance liquid chromatogarphy with the porous polymer resin DVB-MCL-O (or 11-30-0), which is a styrene-divinylbenzene-methyl methacrylate copolymer substituted with hydroxymethyl groups, was studied. This copolymer was compared with the commercial porous polymers Hitachi gel 3011, 3011-0 and 3030. A very small theoretical plate height was obtained by using DVB-MCL-O and methanol-ammonia solution (99:1) as the stationary and mobile phases, respectively. This combination was found to be the most suitable for the rapid separation of condensed aromatic ring compounds.

Related Concepts

Antinociceptive Agents
High Pressure Liquid Chromatography Procedure
Pharmaceutical Preparations
Hydrogen-Ion Concentration
Polymers
Dental Resins
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