Separation of nanorods by density gradient centrifugation

Journal of Chromatography. a
Bin XiongEdward S Yeung

Abstract

The experimental conditions necessary for the synthesis of well-defined nanoparticles are often difficult to control. There is thus a compelling need for post-synthesis separation of nanoparticles polydispersed in size and shape. We demonstrate here both theoretically and experimentally that gold nanorods with diverse aspect ratios can be separated using density gradient centrifugation. By analysing the force balance of a Brownian rod falling in a Stokes flow, we derive a rigorous and predictive model that reveals the quantitative dependency of the nanorod sedimentation rates on their mass and shape. The calculations show that while mass dependency is still the dominating factor during centrifugation, the shape factor is not insignificant. Relatively heavier but long and thin rods could sediment slower than certain size of lighter spheres, and some rods and spheres with different masses and shapes may never be separated. This mass and shape dependency is exploited to separate as-prepared gold nanorod colloids by sucrose gradient centrifugation. Two layers of nanorods with narrow aspect-ratio distributions are obtained.

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Citations

Jun 7, 2012·Nano Letters·Ozge AkbulutGeorge M Whitesides
Dec 3, 2013·Analytical and Bioanalytical Chemistry·Anne-Lena FabriciusThomas A Ternes
Nov 6, 2015·The Journal of Physical Chemistry Letters·Leonardo ScarabelliLuis M Liz-Marzán
Jun 9, 2016·Scientific Reports·James D RobertsonGiuseppe Battaglia
Dec 13, 2016·Chemical Communications : Chem Comm·Yi ShenA B Greytak
Jan 24, 2014·Journal of Physics. Condensed Matter : an Institute of Physics Journal·E Spruijt, P M Biesheuvel
Nov 9, 2018·Biomicrofluidics·Behrouz BehdaniJoontaek Park
Sep 14, 2019·Soft Matter·Chandra S BhattAnil K Suresh
Aug 10, 2016·Analytical and Bioanalytical Chemistry·Monique E JohnsonMichael R Winchester
Jul 3, 2014·Biomaterials Science·Haiyan ChenYueqing Gu
Dec 30, 2020·Chemical Reviews·Cherie R KaganSarah M Thompson
Jan 28, 2014·Langmuir : the ACS Journal of Surfaces and Colloids·Boris N KhlebtsovNikolai G Khlebtsov
Dec 23, 2016·The Journal of Physical Chemistry. C, Nanomaterials and Interfaces·Kayla S B CulverTeri W Odom
Jun 30, 2018·ACS Applied Materials & Interfaces·Kathleen MaleskiYury Gogotsi

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