Separation of opioid peptides utilizing high performance liquid chromatography

International Journal of Peptide and Protein Research
R V LewisS Udenfriend


Chromatographic procedures have been developed for resolving all of the known enkephalins and endorphins on a single column. The effect of eluant pH on the retention times and separation of the enkephalins and beta-endorphin was determined. By combining these separations with a sensitive radioreceptor assay it is possible to assay all of the opioid peptides in the pituitary gland or in various regions of the brain from individual small laboratory animals.


Jul 1, 1981·International Journal of Peptide and Protein Research·D D Gay, R A Lahti
Apr 1, 1989·International Journal of Peptide and Protein Research·T Higa, D M Desiderio
Jul 1, 1983·International Journal of Peptide and Protein Research·B ZiringM J Kreek
Jan 1, 1986·Journal of Neural Transmission·K HenningH Przuntek


Feb 1, 1979·Archives of General Psychiatry·R V LewisS Udenfriend
Dec 1, 1977·FEBS Letters·R P SosaH W Kosterlitz
Feb 1, 1978·Life Sciences·R M KobayashiP Cuatrecasas
Jun 1, 1978·Journal of Chromatography·S GentlemanA Goldstein
Jun 1, 1976·Proceedings of the National Academy of Sciences of the United States of America·A R GintzlerS Spector

Related Concepts

High Pressure Liquid Chromatography Procedure
Opioid Peptide
Radioligand Assay
Neoplasm of Uncertain or Unknown Behavior of Pituitary Gland
Malignant Neoplasm of Pituitary Gland
POMC gene

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