PMID: 7526398Nov 22, 1994Paper

Separation of oxidant-initiated and redox-regulated steps in the NF-kappa B signal transduction pathway

Proceedings of the National Academy of Sciences of the United States of America
M T AndersonL A Herzenberg

Abstract

Studies presented here show that overall NF-kappa B signal transduction begins with a parallel series of stimuli-specific pathways through which cytokines (tumor necrosis factor alpha), oxidants (hydrogen peroxide and mitomycin C), and phorbol ester (phorbol 12-myristate 13-acetate) individually initiate signaling. These initial pathways culminate in a common pathway through which all of the stimulating agents ultimately signal NF-kappa B activation. We distinguish the stimuli-specific pathways by showing that the oxidative stimuli trigger NF-kappa B activation in only one of two human T-cell lines (Wurzburg but not Jurkat), whereas tumor necrosis factor alpha and phorbol 12-myristate 13-acetate readily stimulate in both lines. We propose the common pathway as the simplest way of accounting for the common requirements and properties of the signaling pathway. We include a redox-regulatory mechanism(s) in this common pathway to account for the previously demonstrated redox regulation of NF-kappa B activation in Jurkat cells (in which oxidants don't activate NF-kappa B); we put tyrosine phosphorylation in the common pathway by showing that kinase activity (inhibitable by herbimycin A and tyrphostin 47) is required for NF-kappa B a...Continue Reading

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Citations

Apr 27, 1999·Environmental and Molecular Mutagenesis·G N BijurM V Williams
Apr 22, 2011·Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]·Kyung Don JuHyeyoung Kim
Dec 8, 2005·Pediatric Surgery International·D Weber-MzellM Höllwarth
Feb 24, 2007·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Gholam A PeymanMandi D Conway
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