PMID: 6161585Jan 1, 1980Paper

Separation of two pregnancy-associated proteins with SP1 determinants and the conversion of SP1 beta to SP1 alpha

Archives of Gynecology
A G Ahmed, A Klopper

Abstract

The alpha and beta forms of the pregnancy-associated protein, SP1 which have been previously identified in late pregnancy serum were found to be also present in the placenta. The alpha form was somewhat more difficult to extract, requiring the use of detergents in the extracting buffer. The two variants can be separated by ion exchange chromatography or by gel filtration and distinguished by the different shapes of the precipitation rockets on immunoelectrophoresis. The alpha variant appears to be the larger molecule on gel filtration. When solutions of SP1 are acidified to pH 2.5 the beta form is rapidly converted to the alpha form and the latter is slowly destroyed. It is suggested that SP1 alpha represents the combination of SP1 beta with some other protein present in the placenta and in the serum.

References

Jul 15, 1978·Clinica Chimica Acta; International Journal of Clinical Chemistry·C M TowlerC H Horne
Jun 1, 1978·American Journal of Obstetrics and Gynecology·B TeisnerS E Svehag
Dec 1, 1978·Obstetrical & Gynecological Survey·C H Horne, C M Towler
Jun 1, 1979·Scandinavian Journal of Clinical and Laboratory Investigation·J G WestergaardS E Svehag
Mar 1, 1978·Clinica Chimica Acta; International Journal of Clinical Chemistry·D Bruce, A Klopper
Jan 1, 1972·International Archives of Allergy and Applied Immunology·S A Gall, S P Halbert

❮ Previous
Next ❯

Citations

Sep 15, 1984·Clinica Chimica Acta; International Journal of Clinical Chemistry·S Sørensen, S Trentemøller
May 30, 1986·Clinica Chimica Acta; International Journal of Clinical Chemistry·S W RosenJ C Osborne
Oct 1, 1983·European Journal of Obstetrics, Gynecology, and Reproductive Biology·A G Ahmed, A Klopper
Jul 1, 1982·Journal of Reproductive Immunology·R M Hillier, W R Jones
Apr 1, 1982·Placenta·A G Ahmed, A Klopper
May 1, 1987·British Journal of Obstetrics and Gynaecology·J L HuttenmoserP Bischof
Jul 1, 1983·British Journal of Obstetrics and Gynaecology·A G Ahmed, A Klopper
Apr 1, 1983·British Journal of Obstetrics and Gynaecology·A G Ahmed, A Klopper

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.