Sepsis-3 Septic Shock Criteria and Associated Mortality Among Infected Hospitalized Patients Assessed by a Rapid Response Team

Chest
Shannon M FernandoKwadwo Kyeremanteng

Abstract

Rapid response teams (RRTs) respond to hospitalized patients with deterioration and help determine subsequent management, including ICU admission. In such patients with sepsis and septic shock, the Third International Consensus Definitions for Sepsis and Septic Shock (Sepsis-3) clinical criteria have a potential role in detection, risk stratification, and prognostication; however, their accuracy in comparison with the systemic inflammatory response syndrome (SIRS)-based septic shock criteria is unknown. We sought to evaluate prognostic accuracy of the Sepsis-3 criteria for in-hospital mortality among infected hospitalized patients with acute deterioration. Prospectively collected registry data (2012-2016) from two hospitals, including consecutive hospitalized patients with suspected infection seen by the RRT. We compared the Sepsis-3 criteria with the SIRS-based criteria for prediction of in-hospital mortality. Of 1,708 included patients, 418 (24.5%) met the Sepsis-3 septic shock criteria, whereas 545 (31.9%) met the SIRS-based septic shock criteria. Patients meeting the Sepsis-3 septic shock criteria had higher in-hospital mortality (40.9% vs 33.5%; P < .0001), ICU admission (99.5% vs 89.2%; P < .001), and discharge rates to l...Continue Reading

Citations

May 29, 2019·Critical Care Medicine·Shannon M FernandoKwadwo Kyeremanteng
Nov 20, 2019·Journal of Intensive Care Medicine·Shannon M FernandoKwadwo Kyeremanteng
Oct 9, 2019·Intensive Care Medicine·Shannon M FernandoKwadwo Kyeremanteng
Aug 29, 2019·Critical Care : the Official Journal of the Critical Care Forum·Benjamin GershkovichKwadwo Kyeremanteng
Jan 15, 2020·Critical Care : the Official Journal of the Critical Care Forum·Shannon M FernandoKwadwo Kyeremanteng
Nov 23, 2019·Surgical Infections·Vanessa P HoTanya L Zakrison
Apr 25, 2020·Current Medical Research and Opinion·Josep Darbà, Alicia Marsà
Jul 7, 2018·Critical Care : the Official Journal of the Critical Care Forum·Shannon M FernandoKwadwo Kyeremanteng
Jul 15, 2020·Expert Review of Anti-infective Therapy·Frank Bloos
Feb 23, 2019·Critical Care : the Official Journal of the Critical Care Forum·Shannon M FernandoKwadwo Kyeremanteng
Apr 1, 2020·Journal of Intensive Care Medicine·Mojdeh S HeavnerJonathan H Chow
Feb 4, 2021·Journal of Intensive Care Medicine·Peter M ReardonKwadwo Kyeremanteng
Jun 18, 2019·Entropy·Sergio Martínez-AgüeroCristina Soguero-Ruiz
Feb 26, 2021·Journal of Immunology Research·Yikun ChenJian-An Huang

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