Sepsis and glucocorticoids downregulate the expression of the nuclear cofactor PGC-1beta in skeletal muscle.

American Journal of Physiology. Endocrinology and Metabolism
Michael MenconiPer-Olof Hasselgren

Abstract

Muscle wasting during sepsis is at least in part regulated by glucocorticoids and is associated with increased transcription of genes encoding the ubiquitin ligases atrogin-1 and muscle-specific RING-finger protein-1 (MuRF1). Recent studies suggest that muscle atrophy caused by denervation is associated with reduced expression of the nuclear cofactor peroxisome proliferator-activated receptor-γ coactivator (PGC)-1β and that PGC-1β may be a repressor of the atrogin-1 and MuRF1 genes. The influence of other muscle-wasting conditions on the expression of PGC-1β is not known. We tested the influence of sepsis and glucocorticoids on PGC-1β and examined the potential link between downregulated PGC-1β expression and upregulated atrogin-1 and MuRF1 expression in skeletal muscle. Sepsis in rats and mice and treatment with dexamethasone resulted in downregulated expression of PGC-1β and increased expression of atrogin-1 and MuRF1 in the fast-twitch extensor digitorum longus muscle, with less pronounced changes in the slow-twitch soleus muscle. In additional experiments, adenoviral gene transfer of PGC-1β into cultured C2C12 myotubes resulted in a dose-dependent decrease in atrogin-1 and MuRF1 mRNA levels. Treatment of cultured C2C12 myot...Continue Reading

References

Jan 15, 1996·The Journal of Clinical Investigation·G TiaoP O Hasselgren
Aug 24, 1999·Current Opinion in Clinical Nutrition and Metabolic Care·P O Hasselgren
Mar 13, 2001·Biochemical and Biophysical Research Communications·C G PennerP O Hasselgren
Nov 22, 2001·Proceedings of the National Academy of Sciences of the United States of America·M D GomesA L Goldberg
Jan 17, 2002·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Gail PennerPer-Olof Hasselgren
Feb 13, 2003·Proceedings of the National Academy of Sciences of the United States of America·Michael P CzubrytEric N Olson
Apr 4, 2003·The International Journal of Biochemistry & Cell Biology·Curtis J WrayPer-Olof Hasselgren
Oct 14, 2004·Cell·Bruce M Spiegelman, Reinhart Heinrich
Oct 14, 2004·Cell·Dongsheng CaiSteven E Shoelson
Jan 26, 2005·Journal of Cellular Physiology·Hongmei YangPer-Olof Hasselgren
Feb 18, 2005·The Journal of Biological Chemistry·Shino NemotoToren Finkel
Mar 8, 2005·Muscle & Nerve·R MinnaardM K C Hesselink
Aug 2, 2005·Cell Metabolism·Jiandie LinBruce M Spiegelman
Feb 4, 2006·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Moin U FareedPer-Olof Hasselgren
May 25, 2006·American Journal of Physiology. Endocrinology and Metabolism·Ole Hartvig MortensenNiels Grunnet
Jun 29, 2006·American Journal of Physiology. Endocrinology and Metabolism·Katarina FredrikssonOlav Rooyackers
Sep 16, 2006·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Hongmei YangPer-Olof Hasselgren
Sep 28, 2006·American Journal of Physiology. Endocrinology and Metabolism·Robert A FrostCharles H Lang
Oct 21, 2006·Proceedings of the National Academy of Sciences of the United States of America·Marco SandriBruce M Spiegelman
Nov 23, 2006·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Jennifer M SacheckAlfred L Goldberg
Mar 29, 2008·The Journal of Endocrinology·O SchakmanJ P Thissen
Apr 5, 2008·Mediators of Inflammation·Vitaliy PoylinPer-Olof Hasselgren
Oct 2, 2008·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Darin Van GammerenSusan C Kandarian
Nov 1, 2008·PloS One·Marc LiesaAntonio Zorzano

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Citations

Nov 22, 2011·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Sarah A ReedAndrew R Judge
Sep 29, 2012·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Nima AlamdariPer-Olof Hasselgren
Apr 5, 2013·PloS One·Estibaliz CastilleroPer-Olof Hasselgren
Nov 22, 2013·Seminars in Immunopathology·Petra S Eisele, Christoph Handschin
Dec 15, 2012·Journal of Cellular Biochemistry·Zaira AversaPer-Olof Hasselgren
Jul 3, 2015·Physiological Reviews·O FriedrichL Larsson
Sep 2, 2017·Scientific Reports·Danesh H SopariwalaVihang A Narkar
Dec 7, 2018·Nature Reviews. Gastroenterology & Hepatology·Elena PiccininAntonio Moschetta
Mar 8, 2011·Journal of Cellular Biochemistry·Patricia GonnellaPer-Olof Hasselgren
Apr 25, 2017·Cell and Tissue Research·Igor L BaptistaAnselmo S Moriscot
Aug 30, 2011·Critical Reviews in Clinical Laboratory Sciences·Zaira AversaPer-Olof Hasselgren
Oct 26, 2018·Frontiers in Physiology·Erin L BrownAaron P Russell
Sep 3, 2019·Biological & Pharmaceutical Bulletin·Hiroshi WatanabeToru Maruyama
Apr 10, 2014·International Journal of Molecular Medicine·Hualin SunXiaosong Gu

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