Sepsis associated encephalopathy in an infant with biliary atresia

Brain & Development
Shinpei AbeYuichiro Yamashiro

Abstract

We describe a girl with sepsis-associated encephalopathy complicating biliary atresia. At 4 months of age, decreased consciousness and repetitive seizures of the left upper and lower extremities occurred in association with fever. Pseudomonas aeruginosa was cultured from blood, while bacterial culture was negative and cell counts were normal in cerebrospinal fluid. The interleukin-6 level in the cerebrospinal fluid was markedly elevated. MRI revealed unilateral subcortical white matter lesions in the right hemisphere. She was diagnosed as having sepsis-associated encephalopathy and was treated with dexamethasone and midazolam. She achieved normal psychomotor development until the last follow-up at 19 months of age, whereas mild atrophic changes were observed in the right hemisphere.

References

Aug 31, 2000·Critical Care Medicine·M C PapadopoulosE D Bennett
Mar 27, 2002·Journal of Child Neurology·Jeremy L FreemanLloyd K Shield
Jul 20, 2004·Journal of Neurology, Neurosurgery, and Psychiatry·P F Finelli, D F Uphoff
Jul 28, 2004·Brain & Development·Jun-Ichi KawadaFumio Hayakawa
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Mar 17, 2007·Acta Neurologica Scandinavica·M MizuguchiM Shiomi

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Citations

Sep 4, 2013·Nature Reviews. Neurology·Daniel J StubbsDavid K Menon
Apr 23, 2019·Journal of Central Nervous System Disease·Divine C NwaforCandice M Brown
Jan 3, 2018·The British Journal of Radiology·Debora SanzJoe Brierley

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