Sepsis-Associated Encephalopathy: Insight into Injury and Pathogenesis.

CNS & Neurological Disorders Drug Targets
Lina ZhaoYi Li

Abstract

Sepsis-associated encephalopathy causes long-term health problems in patients with sepsis. This review explores the pathogenesis of sepsis-associated encephalopathy, including its effects on the blood-brain barrier, microglia activation, mitochondrial dysfunction, the inflammatory medium and neurotransmitters and its roles in amino acid balance disorders, hyperammonemia, and intestinal flora imbalance. Understanding the etiology of sepsis-associated encephalopathy may allow the development of adjunctive therapies targeting its underlying mechanism and help develop preventative strategies.

Citations

Jan 23, 2021·Journal of Clinical Medicine·Piero Amodio, Sara Montagnese
May 7, 2021·Critical Reviews in Food Science and Nutrition·Yiwen ChengZongxin Ling

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