Sepsis in Internal Medicine wards: current knowledge, uncertainties and new approaches for management optimization

Annals of Medicine
Vincenzo ZacconeInternal Medicine Sepsis Study Group

Abstract

Sepsis represents a global health problem in terms of morbidity, mortality, social and economic costs. Although usually managed in Intensive Care Units, sepsis showed an increased prevalence among Internal Medicine wards in the last decade. This is substantially due to the ageing of population and to multi-morbidity. These characteristics represent both a risk factor for sepsis and a relative contra-indication for the admission to Intensive Care Units. Although there is a lack of literature on the management of sepsis in Internal Medicine, the outcome of these patients seems to be gradually improving. This is due to Internists' increased adherence to guidelines and "bundles". The routine use of SOFA score helps physicians in the definition of septic patients, even if the optimal score has still to come. Point-of-care ultrasonography, lactates, procalcitonin and beta-d-glucan are of help for treatment optimization. The purpose of this narrative review is to focus on the management of sepsis in Internal Medicine departments, particularly on crucial concepts regarding diagnosis, risk assessment and treatment. Key Messages Sepsis is a life-threatening organ dysfunction caused by a dysregulated host response to infection. The preval...Continue Reading

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Citations

Nov 16, 2019·Panminerva Medica·Alberto TosoniUNKNOWN Internal Medicine Sepsis Study Group
Feb 19, 2021·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·Matteo BoattiniCristina Costa
Jan 19, 2021·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Dmitri GuzTomer Avni
Apr 15, 2021·BMC Geriatrics·Francesca RemelliStefano Volpato
May 1, 2021·Medicina·Alberto Tosoni On Behalf Of The Internal Medicine Sepsis Study Group
Oct 15, 2020·Medicina·Antonio Mirijello On Behalf Of The Internal Medicine Sepsis Study Group

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