Abstract
To evaluate the antioxidant action of N-acetylcysteine and diosmin-hesperidin in an experimental model of sepsis-induced acute kidney injury in rats. The study used 20 Wistar adult male rats divided into the following groups: control (laparotomy with no induction of abdominal sepsis), sepsis (experimental model of sepsis with cecal ligation and puncture), N-acetylcysteine + sepsis and diosmin-hesperidin + sepsis. The evaluation contemplated physiological parameters (temperature, glycemia, and average blood pressure), kidney function (creatinine clearance), oxidative stress (urinary peroxides) and kidney histology. The animals submitted to cecal ligation and puncture (sepsis) presented lower body temperature, lower average blood pressure, reduced creatinine clearance and increased urinary hydrogen peroxide levels. Treatment with diosmin-hesperidin improved kidney function and led to a reduction in the excretion of oxidative metabolites. The present study highlighted the protective antioxidant action of diosmin-hesperidin in the experimental model of sepsis-induced acute kidney injury.
References
Jan 31, 2003·American Journal of Physiology. Renal Physiology·Wei WangRobert W Schrier
Jul 18, 2003·Clinica Chimica Acta; International Journal of Clinical Chemistry·Dibyajyoti BanerjeeJose Jacob
Oct 11, 2008·Free Radical Biology & Medicine·Damon A LowesHelen F Galley
Dec 4, 2008·Free Radical Research·Virginia VanascoSilvia Alvarez
Oct 7, 2009·The Journal of Clinical Investigation·Kent DoiRobert A Star
May 15, 2010·Journal of the American College of Cardiology·Holger ThieleGerhard Schuler
Jul 6, 2010·Biochemical Pharmacology·Joseph H HolthoffPhilip R Mayeux
Apr 23, 2011·American Journal of Physiology. Renal Physiology·Kathryn A SeelyPhilip R Mayeux
Oct 15, 2011·Critical Care : the Official Journal of the Critical Care Forum·Michael Éverton AndradesIvan Spasojević
Apr 13, 2012·Critical Care : the Official Journal of the Critical Care Forum·Masataka NakamuraHiroyuki Hirasawa
Jul 18, 2012·Antimicrobial Agents and Chemotherapy·Cassiane Dezoti FonsecaMaria de Fátima Fernandes Vattimo
Aug 15, 2012·Redox Report : Communications in Free Radical Research·Ramaswamy Anandan, Perumal Subramanian
Oct 18, 2012·JAMA : the Journal of the American Medical Association·Nor'azim Mohd YunosMichael Bailey
Jan 29, 2013·Phytomedicine : International Journal of Phytotherapy and Phytopharmacology·Bidya Dhar SahuRamakrishna Sistla
May 30, 2013·Acta Anaesthesiologica Scandinavica·M PoukkanenUNKNOWN FINNAKI study group
Jun 4, 2013·Lancet·Norbert H LameireRaymond Vanholder
Nov 14, 2013·Critical Care : the Official Journal of the Critical Care Forum·Shigeki KushimotoUNKNOWN JAAM Sepsis Registry Study Group
Dec 11, 2014·Revista da Escola de Enfermagem da U S P·Franciele do Nascimento SantosMaria de Fatima Fernandes Vattimo
Sep 10, 2015·Acta Cirúrgica Brasileira·Letícia Nobre LopesMarcus Vinicius Henriques Brito
Jan 20, 2016·Surgical Infections·Basak ErginelTansu Salman
Feb 24, 2016·JAMA : the Journal of the American Medical Association·Mervyn SingerDerek C Angus
Feb 26, 2016·The Heart Surgery Forum·Abeer M Rababa'hSoon J Park
May 18, 2016·PLoS Medicine·Jean-Louis Vincent
Aug 3, 2016·JAMA : the Journal of the American Medical Association·Anthony C GordonUNKNOWN VANISH Investigators
Apr 2, 2017·Intensive Care Medicine·Rinaldo BellomoAntoine Schneider
Jun 1, 2017·Revista brasileira de enfermagem·Filipe Utuari de Andrade CoelhoMaria de Fátima Fernandes Vattimo
Citations
Dec 17, 2019·Aging·Weifeng YaoZiqing Hei
Sep 24, 2020·Food & Function·Yizhou ZhengLonghuo Wu
Nov 7, 2019·Environmental Science and Pollution Research International·Abdelazim E ElhelalyMohamed M Abdel-Daim
Jun 17, 2020·Archives of Iranian Medicine·Shirinsadat BadriShahram Taheri