Sepsis-induced acute respiratory distress syndrome with fatal outcome is associated to increased serum transforming growth factor beta-1 levels

European Journal of Internal Medicine
Raúl de PabloMelchor Alvarez-Mon

Abstract

TGF-β1 is a promoter of pulmonary fibrosis in many chronic inflammatory diseases. TGF-β1 circulating levels in patients with sepsis-induced Acute Respiratory Distress Syndrome (ARDS) have not been established. In this prospective pilot cohort study, serum bioactive TGF-β1 concentration, determined by sandwich ELISA, was analyzed in 52 patients who fulfilled criteria for septic shock at admission and on days 3 and 7. Of the 52 patients enrolled in the study, 46.1% fulfilled the criteria for ARDS on admission. At ICU admission, there were not statistical differences in TGF-β1 concentrations between septic shock patients with or without ARDS. After 7 days of follow-up in ICU, circulating TGF-β1 levels were significantly higher in patients with sepsis and ARDS than in those without ARDS [55.47 (35.04-79.48 pg/ml) versus 31.65 (22.89-45.63 pg/ml), respectively] (p = 0.002). Furthermore, in septic shock associated ARDS patients, TGF-β1 levels were significantly higher in nonsurvivors than in survivors [85.23 (78.19-96.30 pg/ml) versus 36.41 (30.21-55.47 pg/ml), respectively] (p = 0.006) on day 7 of ICU follow-up. In patients with septic shock, persistent ARDS is accompanied with increased circulating TGF-β1 levels. Furthermore, ARDS ...Continue Reading

References

Aug 1, 1991·Proceedings of the National Academy of Sciences of the United States of America·T J BroekelmannJ A McDonald
Mar 1, 1994·American Journal of Respiratory and Critical Care Medicine·G R BernardR Spragg
Jul 1, 1995·American Journal of Respiratory Cell and Molecular Biology·A SantanaB C Marshall
Jul 21, 1998·JAMA : the Journal of the American Medical Association·G U MeduriE A Tolley
Apr 18, 2000·Chest·S M Opal, V A DePalo
Nov 9, 2000·American Journal of Respiratory and Critical Care Medicine·R P MarshallG J Laurent
Feb 17, 2001·American Journal of Respiratory and Critical Care Medicine·R S Munford, J Pugin
Apr 12, 2003·Critical Care Medicine·Jean-François DhainautJean-Daniel Chiche
Jan 18, 2006·American Journal of Respiratory and Critical Care Medicine·Nveed I ChaudharyJohn E Park
Apr 21, 2006·The New England Journal of Medicine·Peter M Suter
Jun 3, 2006·Intensive Care Medicine·Guillaume MonneretPhilippe Vanhems
Jun 26, 2007·Respirology : Official Journal of the Asian Pacific Society of Respirology·Ritesh AgarwalDheeraj Gupta
Apr 5, 2008·Journal of the American College of Cardiology·Marcin BujakNikolaos G Frangogiannis

❮ Previous
Next ❯

Citations

Sep 4, 2013·Critical Care : the Official Journal of the Critical Care Forum·Fernando Souza-Fonseca-GuimaraesMinou Adib-Conquy
Mar 19, 2016·Journal of Cellular and Molecular Medicine·Cecilia FrejBjörn Dahlbäck
Aug 4, 2015·Revista chilena de pediatría·M Benjamín ErranzR Pablo Cruces
Mar 14, 2013·Critical Reviews in Clinical Laboratory Sciences·James D Faix
Jul 5, 2013·Pediatric Critical Care Medicine : a Journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies·Lincoln S SmithThomas R Martin
Sep 24, 2016·Critical Care Medicine·Xiaoxi ZhuJens Fielitz
Sep 8, 2020·The FEBS Journal·Marcel DoerflingerHamsa Puthalakath
Nov 2, 2017·American Journal of Respiratory Cell and Molecular Biology·Tomeka Suber, Rama K Mallampalli
Feb 6, 2017·Biological & Pharmaceutical Bulletin·Yadan ZhangMing Jin
Jul 31, 2019·International Journal of Molecular Sciences·Giuseppe CastellanoLoreto Gesualdo
Mar 16, 2021·Frontiers in Immunology·Christian B BergmannCharles C Caldwell

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.