Sepsis-induced myocardial depression is associated with transcriptional changes in energy metabolism and contractile related genes: a physiological and gene expression-based approach

Critical Care Medicine
Claudia C dos SantosThomas G Parker

Abstract

Increased nitric oxide production and altered mitochondrial function have been implicated in sepsis-induced cardiac dysfunction. The molecular mechanisms underlying myocardial depression in sepsis and the contribution of nitric oxide in this process however, are incompletely understood. To assess the transcriptional profile associated with sepsis-induced myocardial depression in a clinically relevant mouse model, and specifically test the hypothesis that critical transcriptional changes are inducible nitric oxide synthase-dependent. Laboratory investigation. University affiliated research laboratory. C57/BL6 wild type and congenic B6 129P2-Nos2tm1Lau/J (iNOS) mice. Assessment of myocardial function after 48 hrs of induction of polymicrobial sepsis by caecal ligation and perforation. We compared the myocardial transcriptional profile in C57/BL6 wild type mice and congenic B6 129P2-Nos2tm1Lau/J litter mates after 48 hrs of polymicrobial sepsis induced by caecal ligation and perforation. Profiling of 22,690 expressed sequence tags by gene set enrichment analysis demonstrated that inducible nitric oxide synthase -/- failed to down regulate critical bioenergy and metabolism related genes including the gene for peroxisome proliferato...Continue Reading

References

Mar 18, 1992·JAMA : the Journal of the American Medical Association·R S Hotchkiss, I E Karl
Apr 1, 1984·Annals of Internal Medicine·M M ParkerJ E Parrillo
Nov 7, 1995·Proceedings of the National Academy of Sciences of the United States of America·V E LaubachP A Sherman
Dec 31, 1997·American Journal of Respiratory and Critical Care Medicine·R D PiperW J Sibbald
Oct 28, 1998·The Journal of Clinical Investigation·J N TsoporisT G Parker
Mar 6, 1999·Journal of Applied Physiology·R D PiperW J Sibbald
Aug 14, 1999·Critical Care Medicine·R S HotchkissI E Karl
Apr 20, 2001·Proceedings of the National Academy of Sciences of the United States of America·V G TusherG Chu
Sep 1, 2001·The New England Journal of Medicine·D W Landry, J A Oliver
May 3, 2002·Clinical and Experimental Pharmacology & Physiology·John J Lehman, Daniel P Kelly
May 4, 2002·Heart Failure Reviews·John J Lehman, Daniel P Kelly
May 16, 2002·Heart·E BelcherT Evans
Oct 3, 2002·Current Opinion in Critical Care·Sreenandh KrishnagopalanAnand Kumar
Aug 7, 2004·The EMBO Journal·Motoaki SanoMichael D Schneider
Mar 15, 2005·The Journal of Clinical Investigation·Janice M Huss, Daniel P Kelly
Oct 4, 2005·Proceedings of the National Academy of Sciences of the United States of America·Aravind SubramanianJill P Mesirov
Dec 13, 2005·Critical Care Medicine·Mervyn Singer
Oct 13, 2006·Proceedings of the National Academy of Sciences of the United States of America·Krzysztof LaudanskiRonald G Tompkins
Oct 21, 2006·Proceedings of the National Academy of Sciences of the United States of America·Marco SandriBruce M Spiegelman
Aug 19, 2007·Circulation·M W Merx, C Weber

❮ Previous
Next ❯

Citations

Aug 3, 2012·Chinese Journal of Integrative Medicine·Li-Heng GuoMin-Zhou Zhang
Feb 20, 2010·Critical Care Medicine·Rubin I Cohen
Jan 26, 2013·American Journal of Respiratory and Critical Care Medicine·Osamu TakasuRichard S Hotchkiss
Dec 3, 2011·American Journal of Respiratory Cell and Molecular Biology·Armand Mekontso DessapJoe G N Garcia
Jul 16, 2011·The Veterinary Clinics of North America. Small Animal Practice·Barret J Bulmer
May 28, 2016·Clinics in Chest Medicine·Kimberly E Fenton, Margaret M Parker
May 6, 2014·Journal of Critical Care·Elio AntonucciSabino Scolletta
Oct 14, 2016·American Journal of Respiratory and Critical Care Medicine·Hajera AmatullahUNKNOWN Canadian Critical Care Translational Biology Group
Jan 10, 2017·Critical Care Medicine·Scot J MatkovichDouglas L Mann
Sep 19, 2012·Pathobiology : Journal of Immunopathology, Molecular and Cellular Biology·Mara R N CelesMarcos A Rossi
May 29, 2018·International Journal of Immunopathology and Pharmacology·Andrea GalassiVittorio Fineschi
Jan 9, 2019·Intensive Care Medicine Experimental·Jane FisherPeter Bentzer
May 23, 2012·Critical Care Medicine·Lonneke SmedingClaudia C dos Santos
Dec 31, 2017·Journal of Anesthesia·Koji KidoTokujiro Uchida
Mar 15, 2012·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Martina WeberMichael Bauer
Aug 21, 2019·Intensive Care Medicine Experimental·Thi Thom TranNathalie Lalevée
Aug 14, 2020·Journal of Cellular Biochemistry·Yingzhou ShiYueliang Shen
Sep 4, 2020·Chinese Medical Journal·Jie WangLong-Xiang Su

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cardiac Remodeling

Cardiac remodeling in response to a myocardial infarction is characterized by progressive ventricular dilatation, cardiac hypertrophy, fibrosis, and deterioration of cardiac performance. Discover the latest research on Cardiac Remodeling here.

Cardiomyopathy

Cardiomyopathy is a disease of the heart muscle, that can lead to muscular or electrical dysfunction of the heart. It is often an irreversible disease that is associated with a poor prognosis. There are different causes and classifications of cardiomyopathies. Here are the latest discoveries pertaining to this disease.