Sepsis is characterized by the increases in percentages of circulating CD4+CD25+ regulatory T cells and plasma levels of soluble CD25

The Tohoku Journal of Experimental Medicine
Koji SaitoShin Kurosawa

Abstract

The function of immune system is to protect hosts from invading microorganisms by destroying infected cells while minimizing damage to tissues. Among immune cells, CD4(+)CD25(+) regulatory T cells (Treg cells) control immune responses by limiting infectious processes. However, it remains unclear whether Treg cells are induced in systemic inflammatory response syndrome (SIRS) or infectious SIRS (i.e. sepsis). SIRS and sepsis are associated with stressful inflammatory conditions. We therefore measured CD25(+) T cells and circulating CD4(+) T cells, along with plasma levels of CD25, interleukin (IL)-6, and IL-10, in 20 septic patients (64 +/- 11 years), 16 SIRS patients (59 +/- 16 years), and control subjects: 13 elderly (60 +/- 16 years) and 14 young volunteers (28 +/- 3 years). Septic patients (23.3 +/- 11.8%, p < 0.01) showed significantly higher percentages of CD25(+) cells among CD4(+) T cells (i.e. Treg cells) than did either young (10.6 +/- 3.7%) or elderly volunteers (11.1 +/- 3.8%). The percentages of Treg cells in septic patients were higher than those in SIRS patients (12.4 +/- 6.9%, p < 0.01). Moreover, plasma levels of soluble CD25 were significantly higher in septic patients, compared to the levels in SIRS patients o...Continue Reading

References

Jun 15, 1990·Science·R H Schwartz
Jun 1, 1993·Immunological Reviews·J F Miller, W R Heath
Nov 1, 1993·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·T KawamuraS Inada
May 1, 1997·Journal of Cardiothoracic and Vascular Anesthesia·D Royston
Dec 23, 1999·Chemical Immunology·H D VolkW D Döcke
Feb 16, 2000·British Journal of Anaesthesia·A AouifiJ J Lehot
Feb 25, 2000·Surgery·E LinS F Lowry
Jun 3, 2000·Annual Review of Immunology·E M Shevach
Sep 16, 2000·Intensive Care Medicine·A C Muller KoboldJ W Tervaert
Feb 17, 2001·American Journal of Respiratory and Critical Care Medicine·R S Munford, J Pugin
Aug 30, 2001·Nature Immunology·K J Maloy, F Powrie
Mar 27, 2003·Nature Reviews. Immunology·Kathryn J Wood, Shimon Sakaguchi
Jul 9, 2003·Critical Care Medicine·Guillaume MonneretAlain Lepape
Mar 3, 2004·European Journal of Immunology·Xin ChenO M Zack Howard
Aug 3, 2004·Nature Medicine·Anne O'Garra, Paulo Vieira
Mar 24, 2005·Nature Immunology·Yasmine Belkaid, Barry T Rouse
Jun 4, 2005·Clinical and Experimental Immunology·R GreggP A Moss
Mar 21, 2006·Clinical Immunology : the Official Journal of the Clinical Immunology Society·Piotr TrzonkowskiAndrzej Myśliwski
May 24, 2006·Anesthesia and Analgesia·Michael SanderClaudia D Spies
Apr 7, 2007·Annals of Surgery·Steven B JohnsonThomas M Scalea

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Citations

Jul 18, 2012·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·Li-Na JiangZhi-Yong Sheng
Mar 28, 2013·Critical Care : the Official Journal of the Critical Care Forum·Martin J LlewelynJonathan Cohen
Feb 11, 2010·Critical Care : the Official Journal of the Critical Care Forum·Charalampos Pierrakos, Jean-Louis Vincent
Jun 1, 2013·PloS One·Franziska KühlhornBarbara M Bröker
Feb 5, 2013·Journal of the International AIDS Society·João Manoel Silva, Sigrid De Sousa dos Santos
Aug 28, 2012·Journal of Microbiology, Immunology, and Infection = Wei Mian Yu Gan Ran Za Zhi·Feng-Ying LengHong-Ping Qu
Apr 7, 2009·Journal of Autoimmunity·Aharon KesselElias Toubi
Jun 25, 2013·The Journal of Pathology·James N FullertonDerek W Gilroy
May 1, 2015·Critical Care : the Official Journal of the Critical Care Forum·Beata MickiewiczUNKNOWN Alberta Sepsis Network
Feb 6, 2017·European Journal of Clinical Investigation·Luis García de Guadiana-RomualdoMaría Dolores Albaladejo-Otón
Oct 1, 2009·Shock·Carl F FortinOlivier Lesur
Sep 22, 2018·Clinical Chemistry and Laboratory Medicine : CCLM·Luis García de Guadiana-RomualdoMaría Dolores Albaladejo-Otón
Mar 18, 2010·Scandinavian Journal of Infectious Diseases·Qiang FuChao Du
Feb 27, 2013·Molecular Medicine Reports·Xiang-Feng LiuHong-Liang Yao
Mar 25, 2015·World Journal of Emergency Medicine·Chao CaoSong-Tao Shou
Mar 29, 2011·Critical Care Clinics·Charles A Adams

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