Septal penetration correction in I-131 imaging following thyroid cancer treatment

Physics in Medicine and Biology
Fiona BarrackSarah McQuaid

Abstract

Whole body gamma camera images acquired after I-131 treatment for thyroid cancer can suffer from collimator septal penetration artefacts because of the high energy of the gamma photons. This results in the appearance of 'spoke' artefacts, emanating from regions of high activity concentration, caused by the non-isotropic attenuation of the collimator. Deconvolution has the potential to reduce such artefacts, by taking into account the non-Gaussian point-spread-function (PSF) of the system. A Richardson-Lucy deconvolution algorithm, with and without prior scatter-correction was tested as a method of reducing septal penetration in planar gamma camera images. Phantom images (hot spheres within a warm background) were acquired and deconvolution using a measured PSF was applied. The results were evaluated through region-of-interest and line profile analysis to determine the success of artefact reduction and the optimal number of deconvolution iterations and damping parameter (λ). Without scatter-correction, the optimal results were obtained with 15 iterations and λ  =  0.01, with the counts in the spokes reduced to 20% of the original value, indicating a substantial decrease in their prominence. When a triple-energy-window scatter-co...Continue Reading

References

Dec 3, 2003·Molecular Imaging·Andreas Markus Loening, Sanjiv Sam Gambhir
Apr 6, 2006·Microscopy Research and Technique·Nicolas DeyJosiane Zerubia
Jan 1, 1991·IEEE Transactions on Medical Imaging·K OgawaS Hashimoto
Apr 9, 2008·IEEE Transactions on Image Processing : a Publication of the IEEE Signal Processing Society·C Vonesch, M Unser

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