Septic shock of early or late onset: does it matter?

Chest
Oscar Roman-MarchantJean-Louis Vincent

Abstract

To determine possible differences in morbidity and mortality between early and late onset of septic shock in ICU patients. Systematic data collection. Thirty-one-bed, mixed, medicosurgical ICU in a university hospital. All 65 patients who acquired septic shock after admission to the ICU between February 1999 and April 2000. None. Forty-one of the 65 patients presented with septic shock within 24 h of admission to the ICU (early septic shock [ESS]); the other 21 patients acquired septic shock > 24 h after ICU admission (late septic shock [LSS]). Eleven patients had a second episode (7 patients in the ESS group, and 4 patients in the LSS group), and 1 patient in the LSS group had a third episode of septic shock. Patients with ESS had higher APACHE (acute physiology and chronic health evaluation) II (mean +/- SD, 26 +/- 6 vs 20 +/- 6; p = 0.002) and sequential organ failure assessment (SOFA) scores (11 +/- 3 vs 7 +/- 3, p < 0.001) on ICU admission, and a higher blood lactate concentration at the onset of shock (median 3.70 mEq/L; interquartile range, 2.6 to 6.6 mEq/L; vs median, 2.50 mEq/L [interquartile range, 1.8 to 4.0 mEq/L], p = 0.03) than patients with LSS. However, the duration of septic shock (median, 42 h [interquartile r...Continue Reading

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Citations

Jul 19, 2012·Respirology : Official Journal of the Asian Pacific Society of Respirology·Samuel M BrownNathan C Dean
Oct 22, 2005·American Journal of Respiratory and Critical Care Medicine·Jean-Louis Vincent, Edward Abraham
Jul 19, 2006·Critical Care : the Official Journal of the Critical Care Forum·Mohamed Y RadyRichard Helmers
Dec 18, 2013·Indian Journal of Critical Care Medicine : Peer-reviewed, Official Publication of Indian Society of Critical Care Medicine·Anirban Hom Choudhuri, Rajeev Uppal
Feb 27, 2014·Journal of Physiology and Biochemistry·Pierre EyengaJean Paul Viale
Apr 20, 2013·Scandinavian Journal of Infectious Diseases·Merete StorgaardAnnmarie T Lassen
Nov 4, 2009·Expert Review of Anti-infective Therapy·Emanuel P RiversMaria Rudis
Oct 13, 2009·Chest·Jean-Louis VincentCharles L Sprung
Oct 22, 2008·Infection Control and Hospital Epidemiology : the Official Journal of the Society of Hospital Epidemiologists of America·Caroline LandellePhilippe Vanhems
Jul 7, 2017·Journal of Intensive Care Medicine·Lior FuchsDaniel Talmor

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