Septic shock with multiorgan failure: from conventional apheresis to adsorption therapies

Seminars in Dialysis
B G StegmayrRasheed A Balogun

Abstract

Septic shock is often associated with multiorgan failure, a life threatening clinical condition during which there is an imbalance in the proinflammatory and anti-inflammatory cytokines, chemokines, antigens, endotoxins, procoagulant, and anticoagulant factors and also resultant effects of therapeutic intervention like volume overload. Various extracorporeal therapies have shown some positive results as adjunctive therapeutic intervention to traditional antimicrobials in an effort to bring the inflammatory mediators to a homeostatic balance and to improve poor organ perfusion caused by hypotension and thrombosis in the microcirculation. This review focuses on current information on the use of therapeutic apheresis procedures as adjunctive therapy in such clinical situations as well as the exciting prospects for the near future. The sometimes disappointing results of early phase clinical studies may, in some cases, be related to the well known barriers to successful clinical trials in critically ill patients rather than to failure of the novel concept of adjunctive extracorporeal treatment of septic shock. It should be noted that some of the specialized apheresis technologies reviewed in this article are not yet available for cl...Continue Reading

References

Apr 1, 1996·Clinical Cardiology·P Carson
Nov 5, 1999·Critical Care Medicine·J H ReevesJ J Presneill
Jul 12, 2002·Therapeutic Apheresis : Official Journal of the International Society for Apheresis and the Japanese Society for Apheresis·Hiromichi SuzukiKenshi Moriwaki
Aug 21, 2002·JAMA : the Journal of the American Medical Association·Djillali AnnaneEric Bellissant
Oct 10, 2002·Intensive Care Medicine·Rolf BusundEdvard Nedashkovsky
Apr 30, 2003·International Journal of Infectious Diseases : IJID : Official Publication of the International Society for Infectious Diseases·Keishi MiwaTakehiko Uchiyama
Jun 10, 2003·Critical Care Medicine·Bernd G StegmayrTomas Vikerfors
Jun 21, 2003·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Rafael Ponikvar
Jul 25, 2003·Transfusion and Apheresis Science : Official Journal of the World Apheresis Association : Official Journal of the European Society for Haemapheresis·Karl-Hermann StaubachVeit Otto
Aug 3, 2004·Critical Care Medicine·Konrad ReinhartUNKNOWN EASy-Study Group
Aug 5, 2004·The International Journal of Artificial Organs·M C AmoureuxS Szathmary
Jan 12, 2005·Colloids and Surfaces. B, Biointerfaces·Anna NilssonKrister Holmberg
Mar 24, 2005·Transfusion and Apheresis Science : Official Journal of the World Apheresis Association : Official Journal of the European Society for Haemapheresis·Bernd G Stegmayr
Jul 9, 2005·Critical Care Medicine·Thierry CalandraUNKNOWN International Sepsis Forum Definition of Infection in the ICU Consensus Conference
Apr 18, 2006·Journal of Critical Care·Stéphane SoubrierBenoit Guery
Jul 11, 2006·Seminars in Pediatric Infectious Diseases·James D Fortenberry, Matthew L Paden
Aug 19, 2007·Clinical Journal of the American Society of Nephrology : CJASN·Dinna N CruzUNKNOWN North East Italian Prospective Hospital Renal Outcome Survey on Acute Kidney Injury (NEiPHROS-AKI) Investigators
Apr 12, 2008·Critical Care : the Official Journal of the Critical Care Forum·Sean M BagshawUNKNOWN ANZICS Database Management Committee
May 22, 2008·Transfusion and Apheresis Science : Official Journal of the World Apheresis Association : Official Journal of the European Society for Haemapheresis·Bernd Stegmayr
Jun 21, 2008·Advances in Chronic Kidney Disease·Josée BouchardRavindra L Mehta
Feb 13, 2009·Hemodialysis International·Benny Holmberg, Bernd G Stegmayr
Jun 18, 2009·JAMA : the Journal of the American Medical Association·Dinna N CruzClaudio Ronco
Feb 20, 2010·Clinical Journal of the American Society of Nephrology : CJASN·Robert W Schrier
Jun 4, 2010·Contributions to Nephrology·Tohru TaniAngelo Perego
Nov 26, 2010·The New England Journal of Medicine·Glenn M ChertowAlan S Kliger

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Citations

Dec 23, 2015·Annals of Intensive Care·Patrick M HonoreHerbert D Spapen
Feb 20, 2013·Journal of Clinical Apheresis·Amber P SanchezDavid M Ward
Apr 23, 2014·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Chun-Hung ChiuMei-Chin Mong
Oct 8, 2014·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research· YiminMasahiko Watanabe
Nov 4, 2016·Toxicology Mechanisms and Methods·Amr A FouadWalid N Al-Melhim
Jan 13, 2017·Therapeutic Apheresis and Dialysis : Official Peer-reviewed Journal of the International Society for Apheresis, the Japanese Society for Apheresis, the Japanese Society for Dialysis Therapy·Rolf BambauerRalf Schiel
Apr 11, 2014·Nephro-urology Monthly·Zohreh RostamiBehzad Einollahi
May 22, 2020·Indian Journal of Critical Care Medicine : Peer-reviewed, Official Publication of Indian Society of Critical Care Medicine·Sushmita Rs UpadhyaMayur V Prabhu
Jun 6, 2021·Transfusion and Apheresis Science : Official Journal of the World Apheresis Association : Official Journal of the European Society for Haemapheresis·Gail RockBernd Stegmayr

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