PMID: 7014069May 1, 1981Paper

Septicemia in childhood malignancy. Analysis of 101 consecutive episodes

Clinical Pediatrics
J S MiserR L Chard

Abstract

One hundred one consecutive episodes of blood-culture-positive infection were evaluated in 83 children with malignancy between 1972 and 1977. Eighty-two per cent occurred in relapse, and 75% developed when the absolute neutrophil count was less than 500 per microliters. Forty per cent were fatal. Forty-five per cent of the episodes occurring in relapse and 17% occurring in remission were fatal. Of 88 cases of single-organism infection, 46% were due to gram-positive organisms with a 13% mortality (of these, 28% were due to Staphylococcus aureus with a 4% mortality); 52% were due to gram-negative organisms with a 52% mortality; and two episodes were due to fungal organisms with no fatalities. Multiple-organism infection occurred 13 times, of which 11 episodes were fatal. The authors' data confirm observations by others that the organisms most commonly causing blood-culture-positive infection in children with malignancy are S. aureus and Escherichia coli and that infection due to gram-positive organisms, particularly S. aureus, is less than frequency fatal.

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Citations

Apr 1, 1982·Antimicrobial Agents and Chemotherapy·R BolivarG P Bodey
Jul 1, 1990·Archives of Disease in Childhood·S K JacksonE N Thompson
May 1, 1996·Pediatric Hematology and Oncology·G R JonesS N Pusek
May 1, 1997·Journal of Pediatric Hematology/oncology·P WackerJ Humbert
Sep 2, 1985·Klinische Wochenschrift·H H Hennemann

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