Septin 4, the drosophila ortholog of human CDCrel-1, accumulates in parkin mutant brains and is functionally related to the Nedd4 E3 ubiquitin ligase.

Journal of Molecular Neuroscience : MN
Verónica Muñoz-SorianoNuria Paricio

Abstract

Parkinson's disease (PD) is the second most common neurodegenerative disorder. Although most PD cases are sporadic, several loci have been involved in the disease. parkin (PARK) is causative of autosomal recessive juvenile Parkinsonism (ARJP) and encodes an E3 ubiquitin ligase associated with proteasomal degradation. It was proposed that loss of PARK function may lead to the toxic accumulation of its substrates in the brain, thus causing dopaminergic (DA) neuron death. Indeed, the first identified PARK substrate was CDCrel-1, a protein of the Septin family that accumulates in ARPJ brains. Drosophila has been used as a successful model organism to study PD broadly contributing to the understanding of the disease. Consistently, park mutant flies recapitulate some key features of ARJP patients. In this scenario, we previously reported that overexpression of Septin 4 (Sep4), the Drosophila ortholog of CDCrel-1, is toxic for DA neurons and interacts physically with Park, thus suggesting that Sep4 could be a Park substrate in Drosophila. Confirming this hypothesis, we show that Sep4 accumulates in park mutant brains as its human counterpart. Furthermore, we demonstrate that Nedd4, another E3 ubiquitin ligase that may have a role in P...Continue Reading

References

Dec 1, 1995·Molecular Biology of the Cell·H FaresJ R Pringle
May 13, 1999·Nature Neuroscience·C L BeitesW S Trimble
Apr 4, 2000·Nature·M B Feany, W W Bender
Nov 15, 2000·Proceedings of the National Academy of Sciences of the United States of America·Y ZhangT M Dawson
Apr 27, 2001·Nature Structural Biology·V KanelisJ D Forman-Kay
Dec 12, 2001·Molecular and Cellular Biology·Xiao-Rong PengWilliam S Trimble
Mar 19, 2003·Proceedings of the National Academy of Sciences of the United States of America·Jessica C GreeneLeo J Pallanck
Oct 8, 2003·Proceedings of the National Academy of Sciences of the United States of America·Zhizhong DongHansruedi Büeler
Oct 16, 2003·Brain Research. Molecular Brain Research·P ChoiB Wolozin
Dec 29, 2004·Current Biology : CB·Tadashi SakataShigeo Hayashi
Dec 29, 2004·Current Biology : CB·Marian B WilkinMartin Baron
May 25, 2005·Proceedings of the National Academy of Sciences of the United States of America·Alexander J WhitworthLeo J Pallanck
Jul 7, 2005·Traffic·Emily JooWilliam S Trimble
Jul 9, 2005·Proceedings of the National Academy of Sciences of the United States of America·Guang-Ho ChaKyoung Sang Cho
Nov 25, 2006·Developmental Biology·Maria Giovanna Riparbelli, Giuliano Callaini
Feb 13, 2007·Molecular & Cellular Proteomics : MCP·Taras StasykLukas A Huber
Jul 3, 2007·BMC Evolutionary Biology·Fangfang PanMichelle Momany
Nov 22, 2007·The European Journal of Neuroscience·Verónica Muñoz-Soriano, Nuria Paricio
Nov 19, 2008·Parkinsonism & Related Disorders·Jörg B Schulz
Mar 18, 2008·Journal of Neurology, Neurosurgery, and Psychiatry·J Jankovic
May 14, 2009·Nature Reviews. Molecular Cell Biology·Daniela Rotin, Sharad Kumar
Jun 16, 2009·Lancet·Andrew J LeesTamas Revesz
Jun 26, 2009·Disease Models & Mechanisms·Jeehye ParkJongkyeong Chung
Nov 17, 2009·Seminars in Cell & Developmental Biology·Jan R T van WeeringPeter J Cullen
Nov 18, 2010·PloS One·Marcel NakahiraJörg Kobarg
Apr 21, 2011·Molecular Brain·Caroline Fernandes, Yong Rao
Apr 23, 2011·Parkinson's Disease·Verónica Muñoz-Soriano, Nuria Paricio
Sep 29, 2011·Proceedings of the National Academy of Sciences of the United States of America·George K TofarisAlfred L Goldberg

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Citations

Mar 9, 2013·Proceedings of the National Academy of Sciences of the United States of America·Neda JahanshadUNKNOWN Alzheimer’s Disease Neuroimaging Initiative
May 27, 2016·Nature Communications·Bipan Kumar DebGaiti Hasan
Sep 2, 2017·The Biochemical Journal·Nikhil PanickerTed M Dawson

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