Septopremaxillary ligament resection and midfacial growth in a chimpanzee animal model

The Journal of Craniofacial Surgery
M I SiegelD R Lee

Abstract

Data collected from human studies suggests a relationship between a disruption of the septopremaxillary ligament (SPL) attachment and midfacial hypoplasia in complete cleft individuals. The present study investigates the SPL-traction mechanism and midfacial growth in a chimpanzee animal model. Seventeen chimps (7 unoperated controls, 5 shams, and 5 animals with early SPL reaction) were used in the present study. Lateral head x-rays and dental study models were collected quarterly through 1200 days of age. Growth rates (slopes of the linear growth components) were statistically compared across groups. Premaxillary growth rates were significantly (p less than 0.001) reduced in SPL resected animals compared to the other groups. Maxillary growth rates were significantly reduced in both SPL and sham animals compared to unoperated controls. No significant differences were noted for midfacial height. We conclude that SPL resection produced a significant effect on anterior midfacial growth independent of surgical trauma. These data support the concept of early reestablishment of the SPL in primary nasolabial cleft repair.

Citations

Mar 13, 2014·Theoretical Medicine and Bioethics·Jane Johnson, Neal D Barnard
Dec 18, 2015·The Anatomical Record : Advances in Integrative Anatomy and Evolutionary Biology·Christopher HartmanThomas Southard
May 1, 1992·Journal of Oral and Maxillofacial Surgery : Official Journal of the American Association of Oral and Maxillofacial Surgeons·A LoskenM I Siegel
Mar 5, 2016·The Anatomical Record : Advances in Integrative Anatomy and Evolutionary Biology·Austin Foster, Nathan Holton
Feb 22, 2017·Journal of Anatomy·Matthew J GoergenThorsten Grünheid
Jan 26, 2008·Journal of Dental Research·T YamanishiM Kogo
Dec 16, 2010·The Anatomical Record : Advances in Integrative Anatomy and Evolutionary Biology·Nathan E HoltonMary Ann Nieves
Aug 1, 1991·American Journal of Physical Anthropology·M P Mooney, M I Siegel
Jul 4, 2012·Journal of Anatomy·Nathan E HoltonAaron Figueroa
Mar 1, 1992·The Cleft Palate-craniofacial Journal : Official Publication of the American Cleft Palate-Craniofacial Association·M I SiegelD R Lee
Nov 1, 1994·The Cleft Palate-craniofacial Journal : Official Publication of the American Cleft Palate-Craniofacial Association·S LozanoffR Padwal
Jan 1, 1994·The Cleft Palate-craniofacial Journal : Official Publication of the American Cleft Palate-Craniofacial Association·A LoskenM I Siegel
May 26, 2017·Journal of Medical Primatology·Shyamesh KumarEdward J Dick
Oct 6, 2020·The Anatomical Record : Advances in Integrative Anatomy and Evolutionary Biology·Timothy D SmithValerie B DeLeon

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