Abstract
A number of pathogens have been detected in crocodiles, however little is known about their ability to control these pathogens. The interferon stimulated gene (ISG), viperin, has gained attention recently as an important host protein involved in multiple arms of the immune response. Viperin in concert with a number of other ISGs was upregulated in response to viral nucleic acid mimics and sendai virus in the C. porosus cell line, LV-1, indicating an intact early innate response to viral infection in these animals for the first time. Viperin was cloned from the LV-1 cell line and shown to have similar localisation patterns as human viperin, as well as demonstrating extremely high conservation with the human orthologue, excepting at the N-terminus. Interestingly, C. porosus viperin was also able to inhibit Dengue virus replication in vitro, showing a high level of intact functionality for this protein across divergent animal species, and perhaps demonstrating its importance in the early innate response to pathogens in the animal kingdom.
References
Mar 31, 1998·The Journal of General Virology·R C GualanoA D Davidson
Feb 11, 1999·Journal of Virology·P BoudinotA Benmansour
Apr 3, 2001·Nature Reviews. Genetics·D A Kimbrell, B Beutler
Apr 27, 2002·Revue Scientifique Et Technique·F W Huchzermeyer
May 7, 2002·Journal of Virology·Nathalie GrandvauxJohn Hiscott
Jul 23, 2004·Australian Veterinary Journal·C McCowanR F Slocombe
Mar 16, 2005·Journal of Virology·Christopher P ElcoGanes C Sen
Aug 19, 2005·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Karla J HelbigMichael R Beard
Aug 28, 2007·Molecular Phylogenetics and Evolution·Jonas RoosAxel Janke
Dec 7, 2007·PLoS Neglected Tropical Diseases·Joshua FinkMartin L Hibberd
Nov 7, 2008·Journal of Virology·Karla J HelbigMichael R Beard
Dec 17, 2008·The Journal of Biological Chemistry·Ella R Hinson, Peter Cresswell
Nov 19, 2009·Proceedings of the National Academy of Sciences of the United States of America·Ella R Hinson, Peter Cresswell
Jun 11, 2010·Journal of Virology·Dong JiangJu-Tao Guo
Nov 3, 2010·Virology·Zhi ZhouKui Li
Jan 20, 2011·PLoS Neglected Tropical Diseases·A M A NasirudeenDing Xiang Liu
Mar 26, 2011·Immunity·Tatsuya SaitohShizuo Akira
Nov 3, 2011·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Karla J HelbigMichael R Beard
Jan 24, 2012·Journal of Proteomics·Bung-on PrajanbanSompong Thammasirirak
Feb 2, 2012·Genome Biology·John A St JohnDavid A Ray
Feb 14, 2012·Current Opinion in Virology·John W Schoggins, Charles M Rice
May 3, 2013·PLoS Neglected Tropical Diseases·Karla J HelbigMichael R Beard
Aug 7, 2013·Cell Research·Qiu-Hong WanSheng-Guo Fang
Sep 18, 2013·Proceedings of the National Academy of Sciences of the United States of America·Xunyang GuoRui Lu
Oct 11, 2013·Molecular Biology and Evolution·Krishanu MukherjeeBryan Kolaczkowski
Oct 26, 2013·Journal of Molecular Biology·Karla J Helbig, Michael R Beard
Nov 10, 2013·Fish & Shellfish Immunology·Timothy J GreenPeter Speck
Dec 4, 2013·Microbiology and Molecular Biology Reviews : MMBR·Judith VerhelstXavier Saelens
Jul 2, 2014·Nucleic Acids Research·Xiaomei WuZhen-Ming Pei
Citations
Jul 21, 2015·Developmental and Comparative Immunology·Miaomiao LeiShicui Zhang
Dec 8, 2017·Frontiers in Immunology·Subir SarkerKarla J Helbig
Jul 1, 2020·Annual Review of Virology·Efraín E Rivera-SerranoCraig E Cameron
Mar 22, 2019·Frontiers in Immunology·Khalil EslamlooMatthew L Rise
Nov 2, 2019·Scientific Reports·K J HelbigM R Beard
Jan 3, 2018·PloS One·Ebony A MonsonKarla J Helbig
Nov 2, 2020·Immunology and Cell Biology·Keaton M CrosseKarla J Helbig