Sequence analysis and characterisation of virally induced viperin in the saltwater crocodile (Crocodylus porosus)

Developmental and Comparative Immunology
Natalie L MilicKarla J Helbig

Abstract

A number of pathogens have been detected in crocodiles, however little is known about their ability to control these pathogens. The interferon stimulated gene (ISG), viperin, has gained attention recently as an important host protein involved in multiple arms of the immune response. Viperin in concert with a number of other ISGs was upregulated in response to viral nucleic acid mimics and sendai virus in the C. porosus cell line, LV-1, indicating an intact early innate response to viral infection in these animals for the first time. Viperin was cloned from the LV-1 cell line and shown to have similar localisation patterns as human viperin, as well as demonstrating extremely high conservation with the human orthologue, excepting at the N-terminus. Interestingly, C. porosus viperin was also able to inhibit Dengue virus replication in vitro, showing a high level of intact functionality for this protein across divergent animal species, and perhaps demonstrating its importance in the early innate response to pathogens in the animal kingdom.

References

Apr 3, 2001·Nature Reviews. Genetics·D A Kimbrell, B Beutler
Apr 27, 2002·Revue Scientifique Et Technique·F W Huchzermeyer
Jul 23, 2004·Australian Veterinary Journal·C McCowanR F Slocombe
Aug 19, 2005·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Karla J HelbigMichael R Beard
Dec 7, 2007·PLoS Neglected Tropical Diseases·Joshua FinkMartin L Hibberd
Nov 19, 2009·Proceedings of the National Academy of Sciences of the United States of America·Ella R Hinson, Peter Cresswell
Jan 20, 2011·PLoS Neglected Tropical Diseases·A M A NasirudeenDing Xiang Liu
Nov 3, 2011·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Karla J HelbigMichael R Beard
Jan 24, 2012·Journal of Proteomics·Bung-on PrajanbanSompong Thammasirirak
Feb 14, 2012·Current Opinion in Virology·John W Schoggins, Charles M Rice
Sep 18, 2013·Proceedings of the National Academy of Sciences of the United States of America·Xunyang GuoRui Lu
Oct 11, 2013·Molecular Biology and Evolution·Krishanu MukherjeeBryan Kolaczkowski
Oct 26, 2013·Journal of Molecular Biology·Karla J Helbig, Michael R Beard
Dec 4, 2013·Microbiology and Molecular Biology Reviews : MMBR·Judith VerhelstXavier Saelens
Jul 2, 2014·Nucleic Acids Research·Xiaomei WuZhen-Ming Pei

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Citations

Jul 1, 2020·Annual Review of Virology·Efraín E Rivera-SerranoCraig E Cameron
Mar 22, 2019·Frontiers in Immunology·Khalil EslamlooMatthew L Rise
Nov 2, 2019·Scientific Reports·K J HelbigM R Beard
Nov 2, 2020·Immunology and Cell Biology·Keaton M CrosseKarla J Helbig

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