Abstract
Frequent chromosomal aberrations and/or losses of heterozygosity involving the short arm of chromosome 3 in carcinomas of the lung, kidney and other tissues imply that multiple putative tumor suppressor genes may be present on this chromosomal arm. To search for one of these genes, we determined DNA sequences in the genomic region at 3p22-21.3 where we had previously detected a homozygous deletion in a lung cancer cell line. The DNA sequence results of an about 685-kb region indicated that the size of the homozygously deleted segment was 638,489 bp, in which we identified only four genes including the integrin alpha RLC and the trans-Golgi p230 genes, both reported previously. The predicted amino acid sequences of one of the two novel genes showed high homology to villin, a human cytoskeleton protein; those of the other gene, termed HYA22, revealed significant homology to YA22, a hypothetical protein predicted from DNA sequences of Schizosaccharomyces pombe. The computer programs HEXON or GRAIL were able to predict three-fourths of the exons; the smallest exon predicted by either program was 46 base pairs. Repetitive sequences contained in the genomic region included 151 copies of the Alu sequence (1 copy/every 4.5 kb), 19 copi...Continue Reading
Citations
Sep 18, 1998·Biochimica Et Biophysica Acta·Y SekidoJ D Minna
Nov 21, 1998·The EMBO Journal·S SiniossoglouE Hurt
Apr 3, 2004·Molecular and Cellular Biology·Shirin KazemiAntonis E Koromilas
Mar 31, 2004·Proceedings of the National Academy of Sciences of the United States of America·Vladimir I KashubaEugene R Zabarovsky
Apr 11, 2007·Proceedings of the National Academy of Sciences of the United States of America·Youngjun KimJack E Dixon
Aug 1, 2002·Proceedings of the National Academy of Sciences of the United States of America·Jingfeng LiEugene R Zabarovsky
Jan 13, 2015·Disease Markers·Xiaobing YeGuoping Sun
Jul 21, 2000·DNA Sequence : the Journal of DNA Sequencing and Mapping·H D CampbellJ D Hoheisel
May 26, 2006·The EMBO Journal·James ThompsonOlli A Jänne
Oct 25, 2013·Cytoskeleton·Umesh GhoshdastiderRobert C Robinson
Aug 13, 1999·Molecular Cell·M S KoborJ Greenblatt
Jan 11, 2002·Developmental Biology·I E Zohn, A H Brivanlou
Oct 28, 2016·Comparative Biochemistry and Physiology. Part A, Molecular & Integrative Physiology·Chao-Kai KangTsung-Han Lee
Oct 21, 2003·Genes, Chromosomes & Cancer·Stephan ImrehEugene R Zabarovsky
Jan 27, 2004·Journal of Neuroscience Research·Augustine O FernandesAnthony T Campagnoni
Mar 16, 2002·European Journal of Human Genetics : EJHG·Hajnalka KissJan P Dumanski
Jul 19, 2002·The Journal of Gene Medicine·Alexei I ProtopopovEugene R Zabarovsky
Jul 3, 2008·British Journal of Cancer·T J SengM R J Kohonen-Corish
Jun 23, 2004·Oncogene·Vera N SenchenkoEugene R Zabarovsky
May 29, 2003·Oncogene·Vera SenchenkoEugene R Zabarovsky
May 2, 2003·The Journal of Biological Chemistry·Michele YeoGordon N Gill
Aug 4, 1999·FEBS Letters·E BragaL Kisselev
Jun 12, 2013·Cytoskeleton·Shalini NagLeslie D Burtnick
Jul 4, 2007·The Journal of Biological Chemistry·Sudeep P GeorgeSeema Khurana
Apr 7, 2007·Cancer Research·Ken SasaiTom Curran
Apr 6, 2001·Genetics·R W van Nues, J D Beggs