PMID: 8606054Jan 1, 1996Paper

Sequence analysis of a polymorphic Mhc class II gene in Pacific salmon

Immunogenetics
K M Miller, R E Withler

Abstract

Polymorphism of the nucleotide sequences encoding 149 amino acids of linked major histocompatibility complex (Mhc) class II B1 and B2 peptides, and of the intervening intron (548-773 base pairs), was examined within and among seven Pacific salmon (Oncorhynchus) species. Levels of nucleotide diversity were higher for the B1 sequence than for B2 or the intron in comparisons both within and between species. For the codons of the peptide binding region of the B1 sequence, the level of nonsynonymous nucleotide substitution (dN) exceeded the level of synonymous substitution (dS) by a factor of ten for within-species comparisons, and by a factor of four for between-species comparisons. The excess of dN indicates that balancing selection maintains diversity at this salmonid Mhc class II locus, as is common for Mhc loci in other vertebrates. Levels of nucleotide diversity for both the exon and intron sequences were greater among than within species, and there were numerous species-specific nucleotides present in both the coding and noncoding regions. Thus, neighbor-joining analysis of both the intron and exon regions provided phylogenies in which the sequences clustered strongly by species. There was little evidence of shared ancestral ...Continue Reading

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Citations

Jun 27, 2007·Journal of Molecular Evolution·Andres Aguilar, John Carlos Garza
Jun 24, 2006·Immunogenetics·Kristina M MillerAngela D Schulze
Apr 6, 2004·Molecular Phylogenetics and Evolution·Bernard J Crespi, Michael J Fulton
Nov 1, 1996·Developmental and Comparative Immunology·J D HansenL Du Pasquier
Jan 1, 1997·Developmental and Comparative Immunology·U B GodwinT J McConnell
Apr 29, 1999·Developmental and Comparative Immunology·S S RistowG H Thorgaard
Jun 24, 2009·Ecological Applications : a Publication of the Ecological Society of America·Dominic J TollitKristina M Miller
Oct 15, 1998·Proceedings of the National Academy of Sciences of the United States of America·J WuN L Glass
Jan 23, 2016·Biology·Unni Grimholt
Jul 2, 2011·Fish & Shellfish Immunology·Erin K McClellandKristina M Miller
Aug 30, 2008·Fish & Shellfish Immunology·Elisa RandelliGiuseppe Scapigliati
Nov 3, 2004·Fish & Shellfish Immunology·Eva OttováSerge Morand
Dec 17, 2014·Frontiers in Genetics·José M YáñezScott Newman
Feb 24, 2001·The Journal of Immunology : Official Journal of the American Association of Immunologists·B P ShumP Parham
Jun 1, 1999·Evolution; International Journal of Organic Evolution·H E WalshV L Friesen
Nov 24, 2020·Immunogenetics·Unni Grimholt, Morten Lukacs

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