Sequence analysis of nonulosonic acid biosynthetic gene clusters in Vibrionaceae and Moritella viscosa.

Scientific Reports
Marie-Josée Haglund HalsørInger Lin Uttakleiv Ræder

Abstract

Nonulosonic acid (NulO) biosynthesis in bacteria is directed by nab gene clusters that can lead to neuraminic, legionaminic or pseudaminic acids. Analysis of the gene content from a set mainly composed of Aliivibrio salmonicida and Moritella viscosa strains reveals the existence of several unique nab clusters, for which the NulO products were predicted. This prediction method can be used to guide tandem mass spectrometry studies in order to verify the products of previously undescribed nab clusters and identify new members of the NulOs family.

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Datasets Mentioned

BETA
LFI1238

Software Mentioned

Artemis
GePan
Multilocus Sequence Analysis ( MLSA
Galaxy
Molview
PubChem
Glimmer
SVG
BLASTp
Pymol

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