PMID: 9658018Jul 11, 1998Paper

Sequence analysis of the GntII (subsidiary) system for gluconate metabolism reveals a novel pathway for L-idonic acid catabolism in Escherichia coli

Journal of Bacteriology
Christoph BauschT Conway

Abstract

The presence of two systems in Escherichia coli for gluconate transport and phosphorylation is puzzling. The main system, GntI, is well characterized, while the subsidiary system, GntII, is poorly understood. Genomic sequence analysis of the region known to contain genes of the GntII system led to a hypothesis which was tested biochemically and confirmed: the GntII system encodes a pathway for catabolism of L-idonic acid in which D-gluconate is an intermediate. The genes have been named accordingly: the idnK gene, encoding a thermosensitive gluconate kinase, is monocistronic and transcribed divergently from the idnD-idnO-idnT-idnR operon, which encodes L-idonate 5-dehydrogenase, 5-keto-D-gluconate 5-reductase, an L-idonate transporter, and an L-idonate regulatory protein, respectively. The metabolic sequence is as follows: IdnT allows uptake of L-idonate; IdnD catalyzes a reversible oxidation of L-idonate to form 5-ketogluconate; IdnO catalyzes a reversible reduction of 5-ketogluconate to form D-gluconate; IdnK catalyzes an ATP-dependent phosphorylation of D-gluconate to form 6-phosphogluconate, which is metabolized further via the Entner-Doudoroff pathway; and IdnR appears to act as a positive regulator of the IdnR regulon, wi...Continue Reading

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Citations

May 29, 2002·Proceedings of the National Academy of Sciences of the United States of America·Erik van NimwegenEric D Siggia
Jan 22, 2005·Journal of Bacteriology·Elizabeth L Murray, Tyrrell Conway
Mar 19, 2005·Journal of Bacteriology·Anne L BishopGordon Dougan
Mar 29, 2006·Proceedings of the National Academy of Sciences of the United States of America·Seth DeBoltChristopher M Ford
May 5, 2004·Proceedings of the National Academy of Sciences of the United States of America·Dong-Eun ChangTyrrell Conway
Oct 10, 2008·Molecular Plant-microbe Interactions : MPMI·Frédérique Van GijsegemNicole Hugouvieux-Cotte-Pattat
Oct 6, 2012·The Journal of Biological Chemistry·Tetsu ShimizuAkira Nakamura
Dec 17, 2014·Journal of Industrial Microbiology & Biotechnology·Chandresh ThakkerGeorge N Bennett
Feb 11, 2014·Applied Microbiology and Biotechnology·Agne TubeleviciuteJoachim Jose
Oct 6, 2000·Annual Review of Microbiology·M Riley, M H Serres
Aug 2, 2001·Proceedings of the National Academy of Sciences of the United States of America·M J BarnettS R Long
Sep 17, 2002·European Journal of Biochemistry·Yvonne KallbergBengt Persson
Jan 7, 2004·Nature Reviews. Genetics·Michael E WallMichael A Savageau
Nov 18, 2008·Cellular and Molecular Life Sciences : CMLS·B PerssonH Jörnvall
Feb 7, 2014·American Journal of Medical Genetics. Part a·Heather H PuaLinda J B Jeng
Nov 8, 2006·Proceedings of the National Academy of Sciences of the United States of America·Jennifer L ReedBernhard O Palsson
Aug 7, 2003·Applied and Environmental Microbiology·Jung-Kul LeeHyung-Hwan Hyun
Dec 10, 2013·Journal of Bacteriology·Peter L FreddolinoSaeed Tavazoie
Apr 19, 2017·Scientific Reports·Mehmet U CaglarClaus O Wilke
Jul 11, 1998·Journal of Bacteriology·N Peekhaus, T Conway
Dec 1, 2004·EcoSal Plus·M-A Mandrand-BerthelotN Hugouvieux-Cotte-Pattat
Nov 1, 2005·EcoSal Plus·Tony Romeo, Jacky L Snoep
Oct 22, 2003·Journal of Molecular Biology·Detlef D LeipeL Aravind
Dec 4, 2003·Biochimica Et Biophysica Acta·Shraddha PrakashMilton H Saier
May 10, 2013·ACS Synthetic Biology·Kevin V SolomonKristala L J Prather

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