PMID: 8597639Nov 1, 1995Paper

Sequence analysis of the human hTg737 gene and its polymorphic sites in patients with autosomal recessive polycystic kidney disease

Mammalian Genome : Official Journal of the International Mammalian Genome Society
L F OnuchicS T Reeders

Abstract

DNA sequence analysis of the human Tg737 gene was performed in 36 patients with the autosomal recessive form of polycystic kidney disease (ARPKD). Coding exons and their adjacent splice sites were screened for mutations. Pathogenic exon or splice region mutations were not identified although one exonic and two intronic polymorphic sites were discovered. These results are in agreement with another study that has recently reported linkage to Chromosome (Chr) 6p21-cen in a set of 16 ARPKD families. STS mapping has localized the gene to a YAC contig that includes D13S175 on chromosome 13q12.1. The polymorphisms found in the htG737 gene will permit its future evaluation as a candidate gene for other recessive cystic renal diseases and as a modifier gene in human PKD.

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Citations

Aug 26, 1999·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·C BonuraC Brechot
Jun 10, 2010·Clinical Dysmorphology·Sevim BalciSevinç Bostanoğlu
May 6, 2003·Annual Review of Genomics and Human Genetics·Brent W BisgroveH Joseph Yost
Apr 29, 2011·BMC Public Health·Anita K M ZaidiJoy E Lawn
Nov 2, 2011·American Journal of Medical Genetics. Part a·Vazken M Der KaloustianSerge Melançon
Feb 3, 2009·Current Topics in Developmental Biology·Robyn J QuinlanPhilip L Beales
Apr 7, 2019·Birth Defects Research·Amanda BarbaAriadne Letra
Jan 1, 1997·Calcified Tissue International·E Ogata
Apr 1, 2015·The Journal of Biological Chemistry·Li JiangWolfgang Baehr
Aug 31, 2019·PloS One·Mark E CorkinsRachel K Miller
Nov 30, 2000·Journal of the American Society of Nephrology : JASN·Jeroen NautaLisa M Guay-Woodford

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