Sequence and characterisation of the RET proto-oncogene 5' flanking region: analysis of retinoic acid responsiveness at the transcriptional level

FEBS Letters
G PatroneG Romeo

Abstract

The RET proto-oncogene encodes a receptor tyrosine kinase expressed during neural crest development. RET expression is enhanced in vitro by several differentiating agents, including retinoic acid (RA), which up-regulates RET expression in neuroblastoma cell lines. In the present work we sequenced and analysed a 5 kbp genomic fragment 5' to RET. Three deletion fragments of this region were tested for their RA inducibility in transient transfection assays and failed to support the hypothesis of a direct transcriptional activation. Finally, our functional analysis of a candidate RA response element present in the RET promoter provides new hints for the understanding of the interaction between nuclear receptors and their specific recognition sites.

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Citations

Dec 31, 2009·Development·Carolina RosselotCathy Mendelsohn
Mar 7, 2006·Molecular and Cellular Endocrinology·Mara GiordanoPatricia Momigliano-Richiardi
Oct 14, 2004·Physiological Genomics·Francesca GiacopelliRoberto Ravazzolo
Nov 19, 2004·Human Molecular Genetics·Mercè Garcia-BarceloPaul K H Tam
Jan 4, 2001·Nature Genetics·E BatourinaC Mendelsohn
Oct 9, 2001·The Journal of Biological Chemistry·C S MayanilE G Bremer
Mar 24, 2020·Journal of Proteome Research·Katrin BrenigGereon Poschmann
Oct 14, 2010·Cellular Signalling·Nobuhiko KojimaNorimoto Yanagawa

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