Sequence and embryonic expression of three zebrafish fringe genes: lunatic fringe, radical fringe, and manic fringe

Developmental Dynamics : an Official Publication of the American Association of Anatomists
Xuehui QiuYun-Jin Jiang

Abstract

Drosophila fringe and its homologues in vertebrates code for glycosyltransferases that modify Notch, altering the sensitivity of this receptor protein to its ligands Delta and Serrate and, thereby, playing an essential part in the demarcation of tissue boundaries. We describe the isolation and characterization of three zebrafish (Danio rerio) fringe homologues: lunatic fringe (lfng), radical fringe (rfng), and manic fringe (mfng). In addition to the sites previously described (Prince et al. [2001] Mech. Dev. 105:175-180; Leve et al. [ 2001] Dev. Genes Evol. 211:493-500), lfng is also expressed in the sensory patches of the inner ear. The newly described rfng is expressed in adaxial cells, tectum, rhombomere boundaries, and formed somites, but the expression of mfng is only detectable by reverse transcription-polymerase chain reaction and not by whole-mount in situ hybridization (WISH) during early embryonic development; later, it is expressed in the sensory patches of the ear. In mib mutants, where Notch signaling is defective and rhombomere boundaries fail to form, the rfng expression in hindbrain is almost completely lost. None of the three zebrafish fringe genes is detectably expressed in the posterior presomitic mesoderm, s...Continue Reading

References

Aug 1, 1994·Trends in Genetics : TIG·G Hauptmann, T Gerster
Jul 1, 1995·Developmental Dynamics : an Official Publication of the American Association of Anatomists·C B KimmelT F Schilling
May 29, 1997·Biochemical and Biophysical Research Communications·K SakamotoK Katsube
Jun 26, 1997·Nature·V M PaninK D Irvine
Aug 26, 1998·Developmental Genetics·I PalmeirimO Pourquié
Sep 29, 1998·Nature·B Christen, J M Slack
Jan 20, 1999·Seminars in Cell & Developmental Biology·J Lewis
Mar 25, 1999·Developmental Dynamics : an Official Publication of the American Association of Anatomists·M Z CadinoucheC Tsilfidis
Apr 30, 1999·Science·S Artavanis-TsakonasR J Lake
Feb 17, 2000·Brain Research. Developmental Brain Research·Y IshiiN Osumi
May 17, 2000·Experimental Hematology·N SinghS E Egan
Jul 6, 2000·Developmental Dynamics : an Official Publication of the American Association of Anatomists·B FavierD Dhouailly
Aug 10, 2000·Nature·D J MoloneyT F Vogt
Feb 13, 2001·Brain Research. Molecular Brain Research·T MikamiN Itoh
Jun 27, 2001·Nature Neuroscience·L M ZeltserA Lumsden
Jun 29, 2001·Mechanisms of Development·V E PrinceT F Vogt
Nov 1, 2001·Annual Review of Cell and Developmental Biology·K D Irvine, C Rauskolb
Nov 1, 2001·Annual Review of Cell and Developmental Biology·O Pourquié
Aug 21, 2003·Development Genes and Evolution·Françoise Mazet, Sebastian M Shimeld
Oct 1, 2003·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Bruce AppelAndrew J Latimer
Dec 31, 2003·Developmental Biology·Padmashree C G RidaYun Jin Jiang

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Citations

Nov 14, 2008·Molecular Genetics and Genomics : MGG·Junmo HwangSanggyu Lee
Aug 7, 2009·Molecular Biology of the Cell·Chiaw-Hwee LimYun-Jin Jiang
May 23, 2013·Science Signaling·Jose F de Celis
Jun 26, 2009·Development·Nikolas NikolaouDavid G Wilkinson
Aug 30, 2005·Developmental Biology·Dörthe JülichUNKNOWN Tübingen 2000 Screen Consortium
Nov 9, 2007·Trends in Cell Biology·Andrew Mara, Scott A Holley
May 9, 2007·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Scott A Holley
Oct 21, 2009·The Journal of Comparative Neurology·Ulrike J Sienknecht, Donna M Fekete
Dec 25, 2009·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Fatma O KokHoward I Sirotkin
Feb 17, 2007·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Christina LillesaarLaure Bally-Cuif

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