PMID: 7528047Jul 1, 1994Paper

Sequence and expression of human hair keratin genes

Journal of Dermatological Science
P E BowdenM B Hodgins

Abstract

Normal hair growth and differentiation requires co-ordinate expression of many hair specific structural protein genes. It has been established that one of the 4 major groups of hair structural proteins, low-sulphur hair keratins, belongs to the intermediate filament (IF) multigene family. Hair keratin IF proteins differ from those of other epithelia as they contain cysteine-rich terminal domains allowing more extensive disulphide bonding to the high-sulphur hair matrix proteins. Until recently, little information concerning the primary sequence of hair keratins was available but cloning of some mouse hair and sheep wool keratins has now been reported. Using these sequences, we have polymerase chain reaction (PCR) amplified genomic fragments of human hair-specific keratin IF genes and isolated cosmid clones containing full length genes. We have sequenced part of these genes and studied their expression in human hair follicles. Hair specific keratin fragments were amplified from placental gDNA by PCR primed with synthetic oligonucleotides. Fragments were cloned and sequenced after ligation into pGEM-3Z and labelled riboprobes were generated for in situ hybridization on human skin sections. A human cosmid library was screened with...Continue Reading

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Citations

May 8, 1999·The British Journal of Dermatology·B CribierE Grosshans
Feb 1, 1997·Differentiation; Research in Biological Diversity·M A RogersJ Schweizer
Mar 2, 2005·The Journal of Investigative Dermatology·Paul E Bowden
Sep 28, 2016·Environmental Science & Technology·Alain ManceauJean-Paul Bourdineaud
Oct 3, 1998·The Journal of Biological Chemistry·M A RogersJ Schweizer
Jul 1, 1997·The British Journal of Dermatology·G E WestgateI M Leigh
Nov 5, 2017·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Alexander MuckenhuberWilko Weichert
Nov 12, 1998·Differentiation; Research in Biological Diversity·H KurzenW W Franke
May 1, 2019·ACS Applied Materials & Interfaces·Feiyan GaoShilei Hao

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