Sequence and expression of the CAPA/CAP2b gene in the tobacco hawkmoth, Manduca sexta

The Journal of Experimental Biology
P K Loi, N J Tublitz

Abstract

The gene coding for cardioacceleratory peptide 2b (CAP2b; pELYAFPRV) has been isolated and sequenced from the moth Manduca sexta (GenBank accession #AY649544). Because of its significant homology to the CAPA gene in Drosophila melanogaster, this gene is called the Manduca CAPA gene. The Manduca CAPA gene is 958 nucleotides long with 29 untranslated nucleotides from the beginning of the sequence to the putative start initiation site. The CAPA gene has a single open reading frame, 441 nucleotides long, that codes for a predicted precursor protein of 147 amino acids. The predicted prepropeptide encodes a single copy of each of three deduced propeptides, a CAP2b propeptide, with a Q substituted for an E at the N-terminus (QLYAFPRVa), and two novel CAP2b-related propeptides (DGVLNLYPFPRVa and TEGPGMWFGPRLa). To reduce confusion and to adopt a more standardized nomenclature, we rename pELYAFPRVa as Mas-CAPA-1 and assign the names of Mas-CAPA-2 to DGVLNLYPFPRVa and Mas-PK-1 (Pyrokinin-1) to TEGPGMWFGPRLa. The spatial and temporal expression pattern of the CAPA gene in the Manduca central nervous system (CNS) was determined in all major post-embryonic stages using in situ hybridization techniques. The CAPA gene is expressed in a total ...Continue Reading

References

Jun 1, 1991·Trends in Neurosciences·N TublitzA W Sylwester
Jan 1, 1993·Molecular Neurobiology·M D WhimP E Lloyd
Feb 17, 2000·Annals of the New York Academy of Sciences·R NicholsI A Lim
Apr 18, 2002·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Laura KeanJulian A T Dow
Jul 12, 2002·Insect Biochemistry and Molecular Biology·Francesc IglesiasEmmanuelle Jacquin-Joly
Apr 30, 2004·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Anthony C ClarkJohn Ewer
Jan 1, 1987·Proceedings of the National Academy of Sciences of the United States of America·J StangierR Keller

❮ Previous
Next ❯

Citations

Jan 29, 2011·Cell and Tissue Research·Victor N Ierusalimsky, Pavel M Balaban
May 19, 2010·Proceedings of the National Academy of Sciences of the United States of America·Jean-Paul PaluzziIan Orchard
Apr 11, 2014·PloS One·Man-Yeon ChoiReinhard Predel
Jan 25, 2014·Cell and Tissue Research·Erica HellmichRussell Jurenka
Jan 10, 2012·General and Comparative Endocrinology·Jean-Paul V Paluzzi
Apr 6, 2013·General and Comparative Endocrinology·Shireen-A DaviesJulian A T Dow
Dec 17, 2009·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Juan P IanowskiIan Orchard
Aug 23, 2020·Cell and Tissue Research·Dick R Nässel, Meet Zandawala
Dec 20, 2013·The Journal of Experimental Biology·Shireen A DaviesJulian A T Dow
Feb 17, 2006·The Journal of Experimental Biology·Jean-Paul Paluzzi, Ian Orchard

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.