PMID: 8601731Feb 1, 1996Paper

Sequence and expression patterns of mouse SPR1: Correlation of expression with epithelial function

The Journal of Investigative Dermatology
T KartasovaT Kuroki

Abstract

A final event in the terminal differentiation of stratified squamous epithelia is the formation of a cornified cell envelope, which is a complex of several proteins cross-linked together by transglutaminases. One set of proteins is the family of small proline rich (SPR) proteins. In human foreskin epidermal cell envelopes, SPRs serve as cross-bridging proteins among the more abundant loricrin. In order to study further their evolution and expression, we have isolated and sequenced cDNAs encoding two mouse SPR1 proteins, SPR1a and SPR1b Comparative sequence analysis showed the preservation of the overall structure of mammalian SPR1 proteins with highly conserved termini and a central peptide domain repeated 13 (SPE1a) or seven (SPR1b) times. Tissues obtained from mouse fetal, newborn, and adult skin were tested by Northern blot analyses, in situ hybridization and immunohistochemistry using an antibody raised to a synthetic peptide corresponding to the C terminus of the SPR1a protein. Skin expression was first detected in fetal periderm in anagen hair follicles of newborn and older mice, and in the thickened epidermis of the lip and footpad, but no signal was detected in interfollicular trunk epidermis. High levels of SPR1a expre...Continue Reading

References

Oct 1, 1992·Nature Genetics·C Backendorf, D Hohl
Nov 15, 1992·Proceedings of the National Academy of Sciences of the United States of America·K W MarvinA M Jetten
Aug 11, 1987·Nucleic Acids Research·T KartasovaP van de Putte
Jul 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·L J McKinley-GrantP M Steinert
Aug 15, 1986·Cell·R L Eckert, H Green
May 1, 1988·Molecular and Cellular Biology·T KartasovaP van de Putte
Jan 1, 1984·Proceedings of the National Academy of Sciences of the United States of America·J G ZettergrenK D Wuepper
Apr 1, 1995·Experimental Cell Research·M YaarB A Gilchrest
Jul 1, 1994·The Journal of Investigative Dermatology·K NonomuraS Hirose
May 1, 1993·The Journal of Investigative Dermatology·R L EckertJ F Welter
Nov 15, 1993·Proceedings of the National Academy of Sciences of the United States of America·K Yoneda, P M Steinert
Oct 1, 1993·American Journal of Respiratory Cell and Molecular Biology·J TesfaigziD M Carlson
Jun 1, 1993·Experimental Cell Research·M YaarB A Gilchrest

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Citations

Aug 1, 1997·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·C Byrne
Dec 10, 1999·Molecular Biology of the Cell·P M Steinert, L N Marekov
Jan 2, 2001·Critical Reviews in Oral Biology and Medicine : an Official Publication of the American Association of Oral Biologists·R B Presland, B A Dale
Apr 2, 2005·Nature Reviews. Molecular Cell Biology·Eleonora CandiGerry Melino
Oct 3, 2013·Archives of Dermatological Research·Fernanda CarregaroEloiza H Tajara
Jun 5, 1999·Cell Biochemistry and Biophysics·J Tesfaigzi, D M Carlson
Oct 19, 2000·The Journal of Cell Biology·P DjianH Green
Mar 28, 1998·Experimental Dermatology·A Ishida-Yamamoto, H Iizuka
Jul 2, 2003·American Journal of Physiology. Lung Cellular and Molecular Physiology·Yohannes TesfaigziSteven A Belinsky
Nov 8, 2001·Proceedings of the National Academy of Sciences of the United States of America·D MarshallC Byrne
Jun 25, 2003·Cell Stress & Chaperones·Jean-Marc FontaineRainer Benndorf
Nov 9, 2000·The British Journal of Dermatology·M De Heller-MilevD Hohl
Jul 20, 2005·Genesis : the Journal of Genetics and Development·Howard P BadenAlain Viel
Feb 20, 2002·The Journal of Investigative Dermatology·Michal JarnikAlasdair C Steven
Feb 7, 1998·Journal of Structural Biology·R D LeapmanA C Steven
Dec 18, 1998·The Journal of Investigative Dermatology·S KawabeT Kuroki
Jan 1, 1997·The Journal of Investigative Dermatology·A Ishida-YamamotoH Iizuka
Apr 28, 2005·The Journal of Investigative Dermatology·Benjamin JacksonCarolyn Byrne

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