Sequence and structure relatedness of matrix protein of human respiratory syncytial virus with matrix proteins of other negative-sense RNA viruses

Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases
K LatiffR Ghildyal

Abstract

Matrix proteins of viruses within the order Mononegavirales have similar functions and play important roles in virus assembly. Protein sequence alignment, phylogenetic tree derivation, hydropathy profiles and secondary structure prediction were performed on selected matrix protein sequences, using human respiratory syncytial virus matrix protein as the reference. No general conservation of primary, secondary or tertiary structure was found, except for a broad similarity in the hydropathy pattern correlating with the fact that all the proteins studied are membrane-associated. Interestingly, the matrix proteins of Ebola virus and human respiratory syncytial virus shared secondary structure homology.

References

Jan 1, 1987·Journal of Molecular Evolution·D F Feng, R F Doolittle
Jan 1, 1984·Proceedings of the National Academy of Sciences of the United States of America·D EisenbergT C Terwilliger
Nov 1, 1980·Journal of Virology·D J BucherJ F Davis
Jun 22, 2000·Journal of Molecular Biology·L A KelleyM J Sternberg
Jun 23, 2000·Journal of Molecular Biology·R W RuigrokW Weissenhorn
Dec 16, 2000·The EMBO Journal·S ScianimanicoW Weissenhorn
Oct 18, 2001·Protein Science : a Publication of the Protein Society·J LundströmA Elofsson
Mar 22, 2002·The Journal of General Virology·R GhildyalJ Meanger
Aug 16, 2003·Virology·Joanna TimminsWinfríed Weissenhorn

❮ Previous
Next ❯

Citations

Feb 10, 2012·Journal of Virology·Ruchira MitraAntonius G P Oomens
Mar 18, 2011·PloS One·Audrey Bagnaud-BauleGláucia Paranhos-Baccalà
Oct 3, 2009·Hepatology Research : the Official Journal of the Japan Society of Hepatology·Naoki Umeda, Patrick S Kamath
Feb 10, 2007·The FEBS Journal·Nahla M MansourMilton H Saier
Aug 17, 2006·FEMS Microbiology Reviews·Reena GhildyalDavid A Jans
Apr 12, 2016·Molecular BioSystems·Jillian N WhelanMichael N Teng
Jun 29, 2016·FEBS Letters·Ruth E Watkinson, Benhur Lee

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.